Cialis Tadalafil: Enrich Your Knowledge on this Generic Drug
Cialis (Tadalafil) has brought the whole world at its feet by effectively dealing with erectile dysfunction in men. The fantastic Tadalafil first came to limelight by Galxo Wellcome that explored and developed it under the partnership of a biotechnology company ICOS. It was again developed and promoted under the brand name Cialis by Eli Lilly and Company. The two companies then got united to float a joint venture in the name of Lilly ICOS, LLC. The year 2003 was quite memorable for Cialis (Tadalafil) as it got the Food and Drug Administration (FDA) approval for sale in the US for treating erectile dysfunction. Cialis (Tadalafil) works on a man’s central nervous system by inducing the release of chemicals like nitric oxide that mainly contributes to obtaining and maintaining an erection. Nitric oxide, on the other hand, stimulates the production of cyclic Guanosine Monophosphate (cGMP) which is a chemical responsible for the relaxation of smooth muscles in the penis and the blood flow into the pool-like cavernous sinuses, engorging the penis. Tadalafil facilitates the increased blood flow into the penis that doubles the diameter of the spongy chambers. The veins around these chambers are squeezed as a result of this pressure and are unable to discharge the blood out of the penis. Consequently, the penis gets erected to fulfil your sexual desire. There is an enzyme called phosphodiesterase-5 or PDE5 that acts on the cGMP by lowering its level after ejaculation. Other compounds are then released to bring the penis back to its normal condition. Tadalafil inhibits the role of PDE5 to give you a prolonged erection. As with any generic and prescription drugs, certain risk factors, contraindications and side effects are a must. So, it is highly essential to become aware of all these risk factors and discuss them with your physician before commencing Cialis (Tadalafil) treatment. Men with moderate kidney disease are recommended to begin with 5mg dosage of Tadalafil. They shouldn’t consume more than 10mg in less than 48 hours. The maximum dosage amount is even more stringent for men with severe kidney disease. They must steer clear of taking more than 5mg of Tadalafil in any 72-hour period. Moving on, men with liver disease should consult their doctor to determine whether their condition is moderate or severe before starting Cialis (Tadalafil) treatment. For mild or moderate liver patients, the recommended dosage of Cialis is 10mg once a day. Severe liver patients should stay away from this generic drug. Cialis (Tadalafil) is also an effective treatment for pulmonary hypertension as it releases nitric oxide to relax blood vessels and facilitate blood flow to reduce blood pressure. While hypertension is related to high blood pressure, hypotension points to low blood pressure. As hypotension is a side effect of Tadalafil, it indirectly helps to decrease your blood pressure and keep pulmonary hypertension under control. Drinking alcohol, while undertaking Cialis (Tadalafil) treatment, can increase the risks of hypotension. Men who drink more than 5 alcoholic beverages a day can aggravate their problems if taking Tadalafil at the same time. Take the help of your doctor to determine the safe intake of alcohol with Cialis.
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