How Does Dasatinib Work?
If you're wondering how dasatinib works, you're not alone. Most patients are unsure how the drug works and what to expect during treatment. This article covers the drug's effectiveness, interactions with other medications, and side effects. You can learn about dasatinib's effectiveness for treating CML. Read on to learn more. Here are some common side effects and interactions of dasatinib:
Interactions with other medications
A recent study found that dasatinib interacts with 711 other medications, categorized into 226 major interactions, 471 moderate interactions, 14 minor ones, and one alcohol/food interaction. It is difficult to determine the relevance of any given drug interaction to a specific patient. Regardless, patients should talk with their healthcare providers about any changes in their treatment plans before stopping a drug. If a drug interaction does occur, alternative drugs should be considered and a monitoring plan initiated.
Because of the potential interactions with other drugs, women should consider their fertility and avoid pregnancy while using dasatinib. It may harm an unborn child, so breastfeeding should be avoided for at least 2 weeks after cessation of treatment. In addition, dasatinib can cause severe skin reactions, including blistering skin rash, and lightheadedness. Therefore, women should discuss the risks and benefits with their doctors before starting any type of treatment.
Although dasatinib is metabolized via the liver, it is not a P-gp inhibitor. The active metabolite, dasatinib, represents 5% of the AUC (AUC), but is unlikely to play a major role in the pharmacology of dasatinib. The remaining metabolites are inactive, excreted in urine, and are not of pharmacological importance.
Symptoms of side effects
Some of the possible side effects of dasatinib include bleeding. Bleeding from various sites may occur, and patients may require transfusions of red blood cells. Bloody or dark tarry stools are also possible. Bloody vomit is another side effect that may occur in patients using dasatinib. If you notice any of these effects, contact your healthcare provider immediately.
In rare cases, patients may experience muscle damage. Muscle pain, tenderness, weakness, or brown urine may occur while on dasatinib. These symptoms should be reported to your healthcare provider immediately. It's also important to talk to your doctor if you experience any of these symptoms. Dasatinib should be stored in a dry place, away from moisture. It should be stored at room temperature.
During your treatment with dasatinib, you'll be regularly monitored for any side effects. Your doctor will recommend a dosage and frequency of check-ups. They'll also perform blood tests to assess your response to therapy. Your doctor will also order periodic blood work to monitor organ function and your blood cell counts. Buy dasatinib online for taking dasatinib regularly is essential for your overall health.
Effectiveness in treating CML
The CA180-035 study, the largest study of dasatinib in patients with CML-AP, shows that both treatment regimens are equally effective. There are some differences, however. Both regimens induced similar rates of MaHRs, which suggests that patients may not need a transplant. Additionally, patients in the BID arm of the study experienced a higher rate of fluid-retention events than those in the QD arm, though the reason for the difference is not yet known.
The START-C and START-R studies, which were conducted simultaneously, showed that patients receiving a 100-mg-per-day dasatinib dose had similar rates of cytogenetic and hematologic response as those on the 400-mg-per-day regimen. However, there were differences in the rates of adverse events, and dasatinib-treated patients experienced fewer AEs than those who received imatinib.
Although dasatinib has demonstrated efficacy in patients with CML, many patients are still waiting for more information on its effectiveness. Currently, there are no head-to-head clinical trials comparing dasatinib with imatinib, but data from such trials are still limited. However, there are growing interest in these treatments. To gain more insight, a five-year prospective cohort study is underway. It will assess patient outcomes, treatment adherence, and quality of life. This information will help physicians and patients make informed decisions about their own treatment options.