Dilosyn Expectorant

Dilosyn Expectorant is used for the treatment of cough and congestion caused by bronchitis, the common cold and other illnesses. Dilosyn Expectorant contains methdilazine, ammonium chloride and sodium citrate which are used in combination for relieve of cough and congestion.

Dilosyn Expt

Ammonium Chloride/ Methdilazine Hydrochloride/ Sodium Citrate

Dilosyn Expt

100ml

GSK

Expectorant

(per 5 mL) Ammonium Chloride 0.1 g / Methdilazine Hydrochloride 2.5 mg / Sodium Citrate 50 mg

India

Dilosyn Expectorant

I. Introduction to Dilosyn Expectorant

Overview of Dilosyn Expectorant

The Dilosyn Expectorant is a used medicine that helps relieve issues such as cough and congestion in the airways by loosening mucus and making it easier to breathe for people dealing with conditions like colds or bronchitis, where thick mucus can make breathing difficult.

Key ingredients and their role

The Dilosyn Expectorant contains ingredients recognized for their ability to effectively break down mucus in the body. The main ingredient is usually chlorpheniramine maleate, which acts as an antihistamine to reduce airway inflammation. The additional key component, guaifenesin, functions as an expectorant to assist in thinning and loosening mucus in the lungs so that it can be expelled easily through coughing.

Brief history and approval for medical use

The Dilosyn Expectorant has received approval for use from regulatory agencies worldwide because of its proven effectiveness and safety record. It was originally created to address problems that impede the body's natural mucus expulsion process and has become a choice for treating coughs and symptoms related to mucus buildup.

II. Composition of Dilosyn Expectorant

Active ingredients

  • Chlorpheniramine Maleate: An antihistamine that helps relieve allergy symptoms by blocking histamine receptors.
  • Guaifenesin: The active expectorant which facilitates mucus clearance from the respiratory tract.


Inactive ingredients and their purpose

  • Sodium benzoate: A preservative that helps prolong the shelf life of the formulation.
  • Purified water: Acts as the base of the expectorant solution, ensuring solubility and proper dilution.
  • Artificial sweeteners and flavoring: Included to improve the palatability of the medicine, making it more tolerable for patients.

Variations in formulations (if applicable)

Some formulations of Dilosyn Expectorant may vary slightly depending on the manufacturer, particularly with the use of sweeteners or preservatives. In certain markets, sugar-free options are available to cater to diabetic patients.

Chlorpheniramine maleate vs benadryl

Chlorpheniramine maleate is considered one of the most potent antihistamines available on the market, unlike Benadryl.

Chlorpheniramine maleate phenylephrine

Chlorpheniramine Maleate and Phenylephrine are commonly used to treat the symptoms of a cold such, as eyes and runny nose along with relieving sneezing and itching in the nose or throat area. Chlorpheniramine Maleate works effectively to alleviate allergy symptoms, like nose and watery eyes while also providing relief from sneezing.

Chlorpheniramine maleate vs diphenhydramine

Diphenhydramine is an antihistamine that's effective in managing reactions and motion sickness while also aiding sleep and alleviating certain Parkinsons disease symptoms. Chlorpheniramine maleate is known to be the sedative among products.

Chlorpheniramine maleate vs doxylamine succinate

Chlorpheniramine is used to manage allergy symptoms by blocking histamine H1 receptors in the body. If you have trouble sleeping doxylamine can help as it is an antihistamine tablet that aids in treating insomnia which disrupts your ability to fall asleep or stay asleep through the night for a sleep experience.


III. Uses of Dilosyn Expectorant

Primary indications for Dilosyn Expectorant

Dilosyn Expectorant is primarily used to help patients with issues by relieving cough and its associated symptoms. The main goal is to make it easier for the body to effectively clear out thin mucus secretions.

Approved medical uses

Off-label uses of Dilosyn Expectorant

  • Potential off-label applications: Though not officially approved, some medical professionals use Dilosyn to manage chronic obstructive pulmonary disease (COPD) symptoms.
  • Studies or research supporting off-label use: Limited studies suggest that its expectorant properties could benefit other chronic respiratory conditions, though further clinical research is required.

IV. How Dilosyn Expectorant Works

Mechanism of action

Dilosyn Expectorant operates by merging the antihistamine properties of chlorpheniramine to alleviate inflammation and irritation in the tract with guaifenesin's ability to break down mucus effectively. This dual action facilitates the removal of phlegm for patients, resulting in breathing and decreased frequency of coughs.


Impact on the respiratory system

The expectorant works by targeting the linings in the system to make the mucus more liquid and less thickened. This helps make the mucus thinner and easier to expel through coughing.


Breakdown of expectorant function

  • Reduces the stickiness of mucus.
  • Helps in loosening mucus deposits from the bronchi.
  • Promotes efficient airway clearance and decreases cough severity.

V. Chlorpheniramine maleate dosage

Adults usually take 10 milliliters every 6 to 6 hours based o the intensity of their symptoms. Should not surpass four doses in a day.

Dosage adjustments for children

  • Children aged 6-12: 5 mL every 6-8 hours.
  • Children under 6 years: Dosage is generally not recommended without medical advice.

Administration guidelines

Remember to drink a glass of water when taking Dilosyn Expectorant to help loosen mucus. The medicine can be consumed with or, without food; however having it with a meal might lessen stomach irritation for individuals.

Frequency and duration of use

To achieve the outcomes, it's important to use the expectorant at the specified intervals. It's usually fine to use it for days. It's not recommended to continue using it for more than a week without medical guidance.

VI. Chlorpheniramine maleate side effects

Common side effects

Mild to moderate symptoms

In most cases, side effects are mild and transient. Drowsiness and dizziness are the most commonly reported, particularly due to the expectorant's antihistamine component. These effects usually subside as the body adjusts to the medication.

Frequency and duration of side effects

Most side effects tend to be temporary and lessen as the body gets used to the treatment. If the symptoms persist for more than a few days or worsen over time, it is recommended to seek advice.

Serious side effects

When to seek medical attention

If you experience any side effects, such as trouble breathing or intense dizziness, it is essential to seek medical help as they may indicate an adverse response or overdose situation.

Risk factors for severe reactions

  • Pre-existing liver or kidney conditions.
  • Allergies to antihistamines or other components in the formula.
  • Concurrent use of certain medications, such as sedatives or narcotics.


VII. Precautions and Warnings

General precautions for use

Individuals should be careful when using Dilosyn Expectorant if they have existing health issues or are taking medications concurrently. Following the recommended dosage is crucial to prevent any reactions or potential overdose situations.

Important warnings before using Dilosyn Expectorant

  • Do not use if allergic to any components of the product.
  • Avoid operating heavy machinery as drowsiness may impair judgment.
  • Consult a physician before use if pregnant or breastfeeding.

Allergic reactions

If patients have allergies to antihistamines or any ingredients in Dilosyn Expectorant, they should steer clear of it because it could trigger reactions like rash and itching or, in severe situations, anaphylaxis.

Organ-specific risks (liver, kidneys, etc.)

Patients who have issues with their liver or kidney function should be careful when using Dilosyn Expectorant since this medicine goes through these organs for processing purposes and could build up in the body, leading to toxicity issues, without removal mechanisms in place.

VIII. Contraindications of Dilosyn Expectorant

Conditions and factors that prohibit use

People with problems like severe respiratory insufficiency or chronic bronchitis should steer clear of Dilosyn Expectorant because it could worsen their condition by causing more breathing difficulties. If you have glaucoma or struggle with retention problems and are considering taking this medicine without talking to your doctor first. The antihistamine part of Dilosyn Expectorant could make these issues worse or better for you.

Drug interactions and contraindicated medications

Using Dilosyn Expectorant at the time, as monoamine oxidase inhibitors (MAOIs) or other drugs that depress the central nervous system, is not recommended due to the risks of increased drowsiness, cognitive impairment, or even respiratory failure in extreme situations. As a measure, taking medications that interact with guaifenesin or chlorpheniramine maleate—the components of Dilosyn—should also be done with care.


Known hypersensitivity to ingredients

Individuals who have a documented sensitivity to any of the components in Dilosyn Expectorant are advised against using this product. It may lead to reactions such as skin rash or swelling and, in cases of anaphylaxis, requiring urgent medical intervention.

IX. Drug Interactions

Interactions with common medications

When used with Dilosyn Expectorant medication, other medications that impact the system, like sedatives or antidepressants, expectorant can lead to increased drowsiness and central depressant effects due to its antihistamine properties. Patients on blood pressure medications should consider interactions because certain antihypertensive drugs might not work as well when combined with Dilosyn Expectorant.

Food and drink interactions

  • Avoid alcohol consumption during treatment with Dilosyn Expectorant, as it can increase drowsiness and impair cognitive function.
  • Consuming grapefruit or grapefruit juice should also be avoided, as it can interfere with the metabolism of the drug and potentially increase side effects.


Impact of combining with herbal supplements

Certain natural remedies, like St. John wort or valerian root, have calming properties that could be heightened with Dilosyn Expectorant medication. It is recommended that patients seek guidance from a healthcare before mixing remedies, with this medication to prevent any unforeseen reactions.


Chlorpheniramine maleate interactions

There could be a connection between chlorpheniramine and any of the substances:

X. Administration in Special Populations

Administration to Elderly

Adjustments and considerations for elderly patients: Elderly patients are particularly susceptible to the sedative effects of Dilosyn Expectorant. Reduced kidney and liver function in this demographic means the drug may be metabolized more slowly, increasing the risk of adverse effects. It is often recommended to start with a lower dosage and closely monitor the patient for signs of excessive drowsiness or confusion.

Increased risks in elderly populations: Elderly individuals are more likely to experience side effects such as dizziness, dry mouth, and urinary retention. The risk of falls and cognitive impairment should also be taken into account, as the antihistamine in Dilosyn can affect motor skills and alertness.

Administration to Pregnant Women and Nursing Mothers

Safety and risks during pregnancy: Dilosyn Expectorant should be used with caution during pregnancy, especially in the first trimester, when fetal development is at its most sensitive. Limited research exists on the effects of this medication on fetal health, so physicians often recommend alternative treatments during this period.

Potential effects on breastfeeding: While it is not fully established whether Dilosyn’s active ingredients pass into breast milk, nursing mothers are advised to exercise caution. Antihistamines like chlorpheniramine may reduce milk production and could potentially cause drowsiness or irritability in breastfed infants.

Administration to Children

Age-specific dosage recommendations: For children under six years old, the use of Dilosyn Expectorant is not recommended without explicit medical guidance. For children aged 6-12, a reduced dose is typically advised, with close monitoring for any signs of adverse reactions such as excessive drowsiness or paradoxical excitation.

Safety profile in pediatric use: While generally safe when used in recommended doses, children are more prone to experiencing side effects like excitability, insomnia, or irritability. Parents should follow the dosage instructions carefully and consult with a pediatrician if any unusual symptoms arise.

XI. Careful Administration and Handling Precautions

Special care for patients with pre-existing conditions

Patients who have conditions like diabetes or high blood pressure should be careful when taking Dilosyn Expectorant because the mix of antihistamines and expectorants could affect the medications they use for these conditions. It is important to check blood pressure, sugar, and liver enzymes while using this medication.

Handling and storage instructions

Remember to keep Dilosyn Expectorant in a dry location that is shielded from sunlight. Close the bottle after using it to avoid contamination. Store it in a place that children cannot access to prevent consumption.

Disposal guidelines for expired or unused medication

  • Do not pour unused Dilosyn Expectorant down the drain or toilet unless instructed to do so by a pharmacist.
  • Follow local regulations for proper disposal or participate in community drug take-back programs.

Chlorpheniramine maleate pregnancy

Research findings on the subject of use during pregnancy indicate that there is generally no significantly higher risk of birth defects associated with its use. The results from two studies did suggest a slight increase in the likelihood of certain birth defects; however, no consistent pattern has been identified in terms of specific types of birth defects observed.


XII. Overdosage of Dilosyn Expectorant

Symptoms and signs of overdose

Taking much Dilosyn Expectorant can result in a variety of symptoms that range from mild to effects that can appear early as extreme drowsiness, confusion, and dry mouth. More severe consequences include respiratory depression, seizures, or coma. Children are especially at risk from an overdose; even minor excess amounts beyond the recommended dosage can lead to significant complications.

Emergency response and treatment options

If an overdose is suspected, immediate medical intervention is required. Treatment generally involves supportive care, such as activated charcoal to prevent further absorption and, in some cases, gastric lavage. Intravenous fluids and medications to stabilize heart rate and breathing may also be administered.

Long-term risks of overdose

Extended use of an amount could lead to harm to the nervous system as well, as the kidneys or liver. Using Dilosyn Expectorant on a basis may also raise the chances of developing a dependency, on the drug or experiencing long term cognitive issues.

XIII. Storage and Stability of Dilosyn Expectorant

Please keep the product in a place with a temperature range of 15°C to 30°C (59°F to 86°F). Be careful not to let the bottle get too wet or hot, as this might reduce the effectiveness of the ingredients.

Shelf-life and expiration guidelines

When stored properly, Dilosyn Expectorant typically remains effective for two to three years after its production date. Once you open the bottle, it's best to use it within six months for the best results.

Impact of improper storage on efficacy

Storing Dilosyn Expectorant in conditions like sunlight or high humidity can lessen its effectiveness over time as it may cause the active ingredients to break down outside of the recommended temperature range.

Dilosyn Expectorant FAQ

Will chlorpheniramine maleate raise blood pressure?

You might experience the following side effects:

  • Finding it hard to focus.
  • Feeling fatigue.
  • Experiencing dizziness.
  • Having a headache or blurred vision.
  • Loss of appetite.
  • Indigestion.
  • Feeling vomiting.
  • Diarrhea.
  • Abdominal discomfort or dry mouth.
  • Low blood pressure ( faintness). Alterations, in heart rhythm

Will chlorpheniramine maleate make you sleepy?

Chlorphenamine is an antihistamine medication used to alleviate allergy symptoms. It is known for its sedating effects that may cause drowsiness compared to antihistamines.

Why chlorpheniramine maleate is used?

Chlorpheniramine helps alleviate symptoms, like red and itchy eyes and nose as sneezing and a runny nose due to allergies such, as hay fever or the common cold.

When should I take chlorpheniramine maleate?

People typically take the capsules, tablets, or liquid every 4 to 6 hours as required for relief, while the extended-release versions are usually consumed twice a day: once in the morning and once in the evening as needed.

Chlorpheniramine maleate when breastfeeding?

Small doses of chlorpheniramine ranging from 1 to 3 mg are considered safe for breastfeeding mothers. However, it is advised to avoid doses or prolonged usage as it may have effects and possibly reduce milk production for the baby. This risk is higher when combined with sympathomimetics like pseudoephedrine or during the lactation stage.

When to take chlorpheniramine maleate?

The typical pills, tablets, chewable forms, and liquids are usually consumed every 4 to 6 hours based on requirements, while the extended-release tablets and capsules are generally taken twice a day, in the morning and evening, as necessary.

What is chlorpheniramine maleate paracetamol?

Chlorpheniramine CPM), often utilized in settings, helps to reduce pain and fever associated with colds and flu.

What is chlorpheniramine maleate injection?

Chlorphenamine injection is used for treating hives and managing reactions to insect bites and stings as well as angioedema and other reactions to drugs or serums; it also helps with hay fever symptoms like vasomotor rhinitis and intense itching without a clear cause.

What is chlorpheniramine maleate and phenylephrine hcl?

It contains both an antihistamine and a decongestant. It is commonly employed to alleviate symptoms associated with allergies or respiratory illnesses, like colds or sinus congestion. It offers relief from a runny nose, nasal congestion, and sneezes.

What is chlorpheniramine maleate 4 mg used for?

Chlorpheniramine can help with red and itchy eyes and sneezing caused by allergies or a cold. It won't cure the cause or speed up recovery from these conditions, like hay fever or the common cold would do.

What is chlorpheniramine maleate generic for?

Chlorpheniramine is a type of antihistamine utilized to address symptoms like sneezing and itching due to allergies or the common cold; it also helps with eyes and a runny nose.

How long can I take chlorpheniramine maleate?

Please consult a doctor before using chlorphenamine for more than two weeks and seek advice if your symptoms persist or worsen after two weeks of use for cough or cold relief.

How much chlorpheniramine maleate for dogs?

Chlorpheniramine maleate undergoes first-pass metabolism in the body. Chlorpheniramine and its byproducts are mainly eliminated through urine. The suggested dosage for cats is 1 mg, and for dogs, it is between mg.

How much chlorpheniramine maleate is dangerous?

Do not exceed six tablets within a 24-hour period. For children under 12 years old, dosages are adjusted for individuals who may require more frequent intake than adults do based upon the child's age as determined by their doctor's prescription guidelines for chlorphenamine use in children.

How much chlorpheniramine maleate can i take?

Adults and children aged 12 years and above should take one tablet every 4 to 6 hours as the dosage recommendation; it is advised not to exceed 6 tablets within a 24-hour period for safety reasons. Children under the age of 12 or babies who require this medication as adults but in lower doses due to their smaller size and different needs compared to adults.

How chlorpheniramine maleate works?

Chlorpheniramine belongs to a group of drugs known as antihistamines and functions by inhibiting the effects of histamine. A compound in the body for allergy symptoms.

Can you take chlorpheniramine maleate while pregnant?

During pregnancy, research shows that there is generally no risk of birth defects associated with the use of chlorpheniramine.

Can dogs have chlorpheniramine maleate?

Chlorpheniramine and its byproducts are mainly eliminated through urine excretion, and a suggested dosage is 1—mg for cats and—mg for dogs.

Can chlorpheniramine maleate make you sleepy?

Chlorphenamine is a type of antihistamine medication that helps alleviate allergy symptoms by causing drowsiness. Compared to antihistamines, chlorphenamine makes you more likely to feel sleepy.

Can chlorpheniramine maleate cause constipation?

While taking this medication, you might experience sleepiness or lightheadedness, stomach discomfort, or blurry vision; if any of these symptoms persist or worsen over time, please inform your healthcare provider or pharmacist promptly.

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