DP-Anastrazole, Anastrozole

DP-Anastrazole is used for the treatment of breast cancer in post menopausal women. DP-Anastrazole works by reducing estrogen levels produced by the body. DP-Anastrazole does this by blocking the enzyme aromatase.

Arimidex

Anastrazole

Armotraz, DP-Anastrozole, Adova

14, 5, 14

Douglas Pharmaceuticals Ltd

Tablet

1 mg

India

Out of Stock.

DP-Anastrazole, Anastrozole

Introduction

Anastrozo​le has become a component, in the fight against hormone receptor breast cancer due to its precision in pharmaceutical development​. Initially created for its antiestrogen effects​ Anastrozo​le has played a role in treating breast cancer​. With FDA approval in the 1990s​​ this drug marked an advancement in caring for postmenopausal women​​ providing optimism, for outcomes and personalized treatment approaches​​.


Overview of Anastrozole

AnastrozoIe functions as a non-hormonal aromatase blocker that effectively lowers estrogen levels by inhibiting the aromatase enzyme for estrogen production in the body. This method is vital for individuals whose cancer development is driven by estrogen and offers a treatment strategy with effectiveness.

Historical development and approval

Anastroazole's progress was guided by trials that highlighted its effectiveness compared to older treatments, like selective estrogen receptor modulators (SERMs). Through research demonstrating its advantages and manageable side effects profile, Anastrozole earned FDA approval and transformed the approach to treating hormone-sensitive breast cancer.

Composition and Properties

The transition of Anastroloze from the lab to its application in medicine showcases the advancements in innovation, highlighting its unique characteristics and significance in cancer treatment.

Chemical composition of DP-Anastrozole

DP Anastrozole's molecular structure is defined by its benzyl triazole core, which is known for its ability to effectively inhibit enzymes.This specific design aims to interact with the aromatase enzyme to deactivate it.


Physical and chemical properties

Anastrozole is highly praised for being hydrophobic and stable in the body conditions, which helps it get absorbed efficiently and stay in the bloodstream longer than usual. Its characteristics improve how well the body can use it, making it a valuable tool for managing cancer.

Anastrozole Vs Tamoxifen

  • The Target Mechanism differs from Tamoxifen as it inhibits estrogen receptor activity while Anastrozole diminishes estrogen production.
  • AnastrozoIe is usually more effective at preventing cancer from coming in women who have gone through menopause.

Anastrozole Vs Letrozole

Both of these medications work as aromatase inhibitors. Their molecular structures have variations that impact how they work in the body and the results they produce for patients. Anastrozole is generally seen as less potent than Letrozole but is believed to have fewer side effects that are easier for patients to handle.

Anastrozole Vs Exemestane

Exemestane and Anastrozole have differences in their core structure and workings, which affect how patients respond to them and how well they can tolerate the medications.

Anastrozole Vs Arimidex

Arimidex and Anastrozole are essentially the same in their properties, treatment options, and potential side effects.

Anastrozole Alternatives

Based on their situation, patients who cannot tolerate Anastroloze may opt for aromatase inhibitors such as Letrozole or selective estrogen receptor modulators like Raloxifene.

Natural Alternative to Anastrozole

Confident supporters of healthcare recommend phytoestrogens, like those in soy and flaxseed, as natural substitutes that could potentially regulate estrogen levels in the body; nevertheless, the extent of their effectiveness and safety has not been as comprehensively researched as conventional pharmaceutical choices. Understanding the functions of Anastrozole in treating breast cancer sheds light on its importance in cancer care practices and provides optimism for better outcomes for individuals facing this complex illness.

Pharmacological Mechanism

Anastrozole sets itself apart with an approach that focuses explicitly on blocking the aromatase enzyme crucial in producing estrogen hormones in the body. This targeted inhibition plays a role in combating breast cancer that is driven by estrogen receptors and is especially effective in postmenopausal females.

How Anastrozole works in the body

Anastrozole attaches to the aromatase enzyme to stop its function and decrease estrogen production. The decrease in estrogen is essential as it prevents hormone breast cancer cells from getting the estrogen they need to grow.


Interaction with estrogen receptors

Anastrozole works differently compared to agents that directly block estrogen receptors by decreasing the presence of estrogen in the body, targeting receptors specifically. This results in a decrease in tumor growth and may help prevent metastasis from occurring.

Uses of DP-Anastrozole

Anastroloze is not only used to treat cancer but also has applications in medical areas that benefit from its hormone-regulating properties.

Primary indications in hormone receptor-positive breast cancer

Anastrozole, commonly used to treat hormone receptor breast cancer in postmenopausal women, is known to reduce the likelihood of cancer recurrence and enhance survival rates significantly.

Benefits in postmenopausal women

  • Significantly lowering estrogen levels dramatically decreases the chance of breast cancer.
  • Enhancing long-term survival rates by inhibiting cancer cell growth leads to survival chances.

Anastrozole and Sun Exposure

Anastrozole users should be careful when out in the sun, as it can make their skin more sensitive to light and cause reactions. Remember to take steps to protect yourself from the sun's rays.

Anastrozole for Erectile Dysfunction

Anastrozole has been studied in men for its ability to regulate estrogen levels and possibly improve symptoms of dysfunction caused by imbalances.

Anastrozole with Testosterone

Using testosterone alongside in situations can help mitigate the estrogen related effects linked to external testosterone intake like enlarged breasts and retention of too much water.

Anastrozole and Foot Pain

An unusual yet significant consequence may include experiencing foot soreness or discomfort possibly related to altered levels and nerve sensitivity triggered by changes.

Anastrozole Bodybuilding

In the world of bodybuilding, enthusiasts often use Anastrozole to reduce the effects of estrogen when using doses of steroids, which in turn helps in preserving muscle shape and decreasing water retention.

Anastrozole Weight Gain

Weight gain may be a side effect because of hormone changes that can impact metabolism and appetite.


Anastrozole Hair Loss

Some individuals might notice their hair becoming thinner or falling out due to the medication's effects on hormone levels that can affect the health of hair follicles.


Anastrozole uses in Males

Anastrozole is not used for treating breast cancer. It is also more commonly employed to address issues in men related to excess estrogen, like gynecomastia, and regulate hormone levels in testosterone replacement therapy. This broad spectrum of uses for Anastrozole showcases its flexibility in handling conditions linked to estrogen levels and underscores its importance in medical scenarios.

Off-Label Uses

Anastrozole is mainly known for its effectiveness in treating hormone receptor breast cancer in postmenopausal women; however, it is also being researched for potential uses beyond its primary indication to broaden its medical applications.

Exploration of potential in other cancers

Scientists are exploring how Anastrozole could be effective in treating estrogen cancers, like ovarian and endometrial cancer, by studying its ability to slow down tumor growth by suppressing estrogen levels.

Use in male patients with hormone-related conditions

Anastrozole has been researched for its effects in treating gynecomastia and pubertal gynecomastia in men due to imbalances involving estrogen levels.

Anastrozole and Belly Fat

An increasing number of people are showing curiosity about how Anastrozole can help deal with accumulation connected to estrogen levels. In men, high estrogen levels worsen the buildup of belly fat.

Dosage and Administration

The proper dosage and way to use Anastrozole are factors in ensuring its effectiveness and safety in treatment situations.


  • Breast cancer treatment usually involves taking a 1 mg dose until the tumor shows signs of progression.
  • Male hormonal imbalance may require dosages depending on the hormonal issue being addressed.

Adjustments for specific patient populations

Patients with kidney or liver issues may need changes in their medication dosage because these conditions could impact Anastrozole breakdown in the body.

Anastrozole Dosage Bodybuilding

When it comes to bodybuilding practices, Anastrozole is commonly employed in amounts to reduce the estrogen-related impacts of steroid usage, with doses adjusted based on how individuals react to steroid treatment.

Anastrozole for Men Dosage

When it comes to addressing issues, in men, Anastrozole is commonly recommended in doses than those used for breast cancer treatment, usually between 0.25 mg to 1 mg, taken every other day or even weekly.

Anastrozole Dosage with Testosterone

When Anastrozole is paired with testosterone replacement therapy to manage side effects, in the body's hormone balance regulation process, it is essential to adjust the dosage based on serum estrogen levels and how each individual responds to the treatment.

Administration Considerations

Properly managing Anastrozoleis is crucial to ensure it delivers its intended advantages while minimizing any associated hazards.

Special instructions for administration

Anastrozole should be consumed at a time daily. It can be taken with or without food to ensure stable levels in the bloodstream. Following the recommended dosages and avoiding altering the medication without consulting a healthcare professional is essential.

Tips for adherence and efficacy

  • Having your dose simultaneously every day boosts the effectiveness of treatment and maintains its efficiency.
  • Regularly observing hormone levels and potential side effects is essential for customizing the treatment plan to achieve the results.
  • Teaching patients about the side effects and advantages of Anastrozole can help them stick to their treatment plan and effectively deal with any symptoms that may arise.

By controlling the amount of medication and following the suggested instructions for use, Anastrozole Is a crucial element in treating conditions that are sensitive to hormones.

Side Effects of Anastrozole

Anastrozole is an aromatase blocker commonly prescribed for breast cancer treatment. It has various side effects ranging from mild to severe, requiring careful supervision and control.


Common side effects and their management

Frequently experienced reactions consist of flashes and joint pain along with feelings of nausea as potential side effects of the treatment regimen suggested by healthcare providers for managing symptoms, like hot flashes and joint pain, through lifestyle changes and cooling methods or medication intervention if needed.

Serious adverse reactions to be aware of

Severe reactions may involve heart problems and weakening of the bones, so it's important for patients to stay in touch with their healthcare providers and watch out for signs of these issues.

Long-Term Side Effects of Anastrozole

  • Prolonged usage may lead to a decrease in bone mineral density, which could elevate the chances of fractures.
  • Cardiovascular dangers may rise, as indicated by research findings that hint at an uptick in heart-related incidents.

Anastrozole for Men Side Effects

Men may experience side effects such as a decrease in desire and performance issues like dysfunction or mood changes when taking this medication. Monitoring and adjusting the dosage to effectively handle these symptoms is essential.

Anastrozole Side Effects in Females

Women might find that their menopausal symptoms are worsened by factors such as dryness and changes in mood levels. It is essential to consider therapies and lifestyle changes to help alleviate these symptoms.

Interactions with Other Medications

The effectiveness and safety of Anastrozole use can be affected by how it interacts with drugs; hence, it is essential to handle its usage in cases of multiple medication use.

Common drug interactions and contraindications

Anastrozole should not be taken at the same time as treatments containing estrogen because they can negate its benefits, and some antidepressants, known as SSRIs, may impact how Anastrole is processed in the body.


Impact on pharmacokinetics of other drugs

Anastrozole might change how certain medications are processed by the body through CYP enzymes, requiring the doses of those drugs to be adjusted.

Foods to avoid when taking Anastrozole

It is recommended that patients steer clear of foods in phytoestrogens, like soy products, since they could reduce the effectiveness of the medication.

Anastrozole and Alcohol

Alcohol can worsen the side effects of Anastrozole, like flashes and liver strain; it's better to moderate your intake or avoid it altogether.

Anastrozole interactions with Vitamins

It's important to be careful when using vitamins and supplements containing estrogen or impact hormone levels to ensure they don't interfere with the effectiveness of Anastrozole treatment benefits.

Contraindications and Cautions

For safe administration purposes, it's important to be aware of the contraindications and to take care when dealing with groups when giving Anastrozole.


Absolute contraindications for use

Patients with a history of reactions to Anastrozole should avoid using the drug along with women and individuals on estrogen-based treatments due to potential risks.

Cautions in patients with pre-existing conditions

  • Patients with heart issues should be careful when using Anastrozole because it may pose risks to their health.
  • Anastrozole might worsen existing bone density problems and require extra care in managing bone health for people with osteoporosis.

By evaluating its impacts on the body and how it interacts with other medications while being mindful of any limitations or restrictions in usage, Anastrozole continues to be a vital treatment for hormone receptor-positive breast cancer and shows promise for broader applications as studies advance.

Special Populations

When giving Anastrozole to patients, special attention must be paid to groups to guarantee effectiveness and safety.

Considerations for elderly patients

Older individuals might need monitoring because they have a higher chance of developing osteoporosis and experiencing fractures linked to Anastrozole use. They may need to adjust dosages depending on their kidney function and general health to reduce the risk of side effects.


Guidelines for administration to pregnant women and nursing mothers

Women or nursing mothers should not use Anastrozole. It may harm the fetus and can pass into breast milk, posing risks to the baby's health. It's best to explore other treatment options for women in these groups.


Handling and Storage

Handling and storing Anastrozole properly is crucial to ensure its effectiveness and safety.

Proper storage conditions to ensure stability

Anastrozole must be kept at room temperature and shielded from light and moisture. The tablets should be kept in their packaging until they are used to safeguard them from the elements.


Disposal considerations and safety measures

Properly dispose of any unused Anastrozole to avoid ingestion or environmental harm, according to local medication disposal guidelines provided for patients.

Overdose and Management

Excessive intake of Anastrozole may worsen side effects and necessitate urgent medical attention.


Symptoms of overdose

Symptoms of increased toxicity can manifest as dizziness, uncommon fatigue and sudden hormonal imbalances.

Steps for immediate management and treatment

When treating this condition, it is important to offer care that addresses the symptoms and provides support to the individual affected by it. In case of an overdose, it is essential to seek assistance from healthcare experts. One may also consider options such as lavage and the administration of activated charcoal to help prevent any absorption of substances.

Anastrozole Withdrawal Symptoms

Stopping the use of Anastrozole may cause withdrawal symptoms that represent changes in hormone levels within the body.

  • Patients might notice a rebound in estrogen levels, which could result in the return or worsening of symptoms they were experiencing before.
  • Feeling changes and tiredness often occur when the body adjusts to its natural hormone levels after treatment.

It is commonly advised to keep monitoring and consider reducing the medication to minimize these impacts and guarantee a shift away from the drug.

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DP-Anastrazole, Anastrozole FAQ

Do side effects of Anastrozole get worse over time?

The effects of Anastrozole on those undergoing breast cancer treatment may not necessarily worsen with time. In fact, they might even get better as the body adapts to the medication's presence. However, side effects can vary greatly from person to person.

Does Anastrozole cause weight gain?

Anastrozole is often prescribed for breast cancer treatment. It is not usually linked to weight gain as a direct side effect. However, the connection between Anastrole and weight changes can be affected by factors such as status, lifestyle habits, other medications, and metabolic shifts.

Does Anastrozole cause joint pain?

Indeed yes! Anastrozole has been known to trigger discomfort as a side effect in individuals taking this medication for treating hormone receptor-positive breast cancer in postmenopausal women by decreasing estrogen levels.

How long for Anastrozole to work Testosterone

Anastrozole is often taken as Arimidex and can impact testosterone levels quickly; however, the degree and timeframe may differ depending on factors such as metabolism rate and dosage as well as the specific condition being addressed.

How quickly does Anastrozole Cause Bone Loss

Anastrozole can significantly affect bone density by lowering estrogen levels, which is essential for keeping bones healthy; the speed and extent of bone loss as a side effect may differ depending on bone density level, age, gender, and general health condition.

How to deal with side effects of Anastrozole

Dealing with the effects of a medication like Anastrozole is essential when it is used to treat hormone receptor breast cancer in women after menopause and to regulate estrogen in testosterone replacement therapy. This requires employing approaches and tactics.

How long does it take for Anastrozole to work

Anastrozole to usually begins influencing hormone levels between 24 and 48 hours after being taken; however, it may take weeks before any noticeable clinical benefits emerge.

How long does Anastrozole stay in your system

Anastrozole generally remains detectable for 5 to 7 days after intake.

How fast does Anastrozole work

Anastrozole starts impact hormone levels within one to two days.

How long to take Anastrozole

The length of time that someone usually takes Anastrozole Varies, from 5 to 10 years, depending on their health condition and treatment regimen.

How much does Anastrozole reduce recurrence

Anastrozole decreases the chances of breast cancer by half when taken by postmenopausal women with early-stage breast cancer that is hormone receptor-positive compared to not taking any treatment.

How often should you take Anastrozole with Testosterone

Anastrozole is usually consumed once a day in conjunction with testosterone treatment.

How to take Anastrozole

You should take Anastrozole once a day at a time, every day, with or without food.

How much Anastrozole should I take on a cycle

The standard amount of Anastrozole during a cycle can vary; it usually ranges from 0.5 mg to 1 mg daily, depending on how much estrogen control is required. Follow the advice of your healthcare provider regarding dosage.

How effective is Anastrozole

Anastrozole is known for its ability to lower estrogen levels in the body effectively to reduce the likelihood of hormone receptor breast cancer recurrence in women and alleviate estrogen-related side effects in men receiving testosterone replacement therapy successfully saw a 50 percent decrease in breast cancer recurrence risk compared to untreated individuals, in clinical trials.

How fast does Anastrozole Lower Estrogen

Anastrozole can start reducing estrogen levels within 24 to 48 hours after the dose.

How much Anastrozole to take on a cycle

In bodybuilding circles, the usual amount of Anastrozole Used during a cycle to manage estrogen ranges from 0.5 mg to 1mg every day, depending on how one responds and their estrogen levels. It's crucial to adhere to the dosage advice of a professional for safety and optimal results.

How common is Hair Loss with Anastrozole

Hair loss caused by taking Anastrozole is seen as an occurrence among patients. It presents itself with differing levels of intensity in only a small number of cases. The extent of hair loss experienced by those affected typically falls within the range of mild to severe.

How much Anastrozole should I take

The usual amount of Anastrozole for grown-ups is 1 mg per day taken by mouth for breast cancer therapy purposes; however, the dosage may differ for purposes such as regulating estrogen levels in men receiving testosterone treatment. You should seek advice from your healthcare provider to determine the dosage tailored to your situation.

How long do you take Anastrozole

A person usually takes Anastrozole varies between 5 and 10 years, based on their needs and prescribed treatment regimen.

How to prevent Hair Loss while on Anastrozole

Avoid hair loss when using Anastrozole involves methods to handle and potentially reduce this side effect as

  • Delicate Hair Care
  • Nutrition and Scalping Care
  • Stress management techniques
  • Seeking advice from a specialist and reviewing medications

What are the major side effects of Anastrozole

The main side effects of Anastrozole include:

  • Bone related effects
  • Muscle and joint discomfort
  • Hot flashes and sweating
  • Elevated cholesterol levels
  • Digestive problems
  • Alterations in mood leading to depression
  • Fatigue
  • Cardiovascular
  • Liver changes

What Vitamins should not be taken with Anastrozole

Anastrozole is a type of aromatase inhibitor that is commonly prescribed for treating forms of breast cancer. The intake of vitamins and supplements may influence its effectiveness and potential side effects. Although there isn't evidence of interactions, between vitamins and Anastrozole it's advisable to be cautious with supplements like:

  • Vitamin D
  • Vitamin E
  • Multivitamins containing Soy or Phytoestrogens
  • Calcium with Vitamin D

What happens if you take 2 Anastrozole by mistake

If you happen to consume two doses of Anastrozole by mistake, it is unlikely to cause harm; however, it is essential to watch out for any side effects. Anastrozole is usually prescribed at a low dosage of 1 mg per day, and ingesting more than the recommended amount is not likely to lead to any serious negative effects.

What is Anastrozole used for in Males

Anastrozole is mainly utilized in men to treat conditions associated with levels of estrogen in the body. While its primary use is for treating breast cancer in women it also has off label applications, for men. These include:

  • Gynecomastia
  • Testosterone Therapy
  • Hypogonadia
  • Infertility.

What are the side effects of Anastrozole

Anastrozole may result in side effects, like any other medication does, for individuals; the severity and nature of these side effects can differ from person to person. A number of more severe side effects linked to Anastrozole include

  • Hot Flashes
  • Joint and Muscle Pain
  • Fatigue
  • Nausea
  • Headaches
  • Weakness Bone Pain
  • Sweating
  • Sleep Problems
  • Weight Gain

What are the long-term side effects of Anastrozole in Females

Term adverse outcomes of Anastrozole in women include:

  • Bone weakening (osteoporosis)
  • Heart health risks
  • Pain in joints and muscles (arthralgia and myalgia)
  • Hot flashes and sweating
  • Changes in mood and feelings of depression
  • Dryness in the vagina and sexual difficulties
  • Feelings of fatigue effects
  • On function, there is a higher chance of fractures
  • Weight increase.

What happens When you stop taking Anastrozole

Once you discontinue using the Anastrozole medication treatment regimen for breast cancer management and prevention of recurrence:

  • You might notice a normalization of estrogen levels in your body following cessation of the medication intake
  • Be mindful of cancer symptoms re-emerging if the drug is discontinued prematurely or without consulting a healthcare professional.
  • Expect a decrease in the side effects linked to the medication
  • Make sure to stay under close observation by medical experts to handle any alterations in your health condition effectively.

What should you avoid when taking Anastrozole?

When using Anastrozole medication, it's best to steer of:

  • Estrogen Supplements
  • Grapefruit or Grapefruit Juice
  • Alcohol intake
  • Certain medications, like Tamoxifen and other estrogen blockers.

What happens if you miss a dose of Anastrozole

If you forget to take a dose of Anastrozole Medication and remember, except if your next dose is coming up shortly, then it's better to skip the missed one and stick to your dosing routine instead of taking two doses at once to compensate for the missed dose.

What does Anastrozole do for a Man

Anastrozole can be beneficial for men by lowering estrogen levels to address issues such as gynecomastia ( breast tissue growth) and to help manage symptoms associated with estrogen levels in the body. It is sometimes prescribed off-label to boost testosterone production in men dealing with low testosterone levels.

What is Anastrozole used for in Bodybuilding

Anastrozole is commonly employed in bodybuilding to lower estrogen levels, prevent gynecomastia ( breast enlargement), improve muscle definition by reducing water retention, and maintain a testosterone-to-estrogen ratio when using steroids for muscle growth goals.

What Supplements should not be taken with Anastrozole

It is not recommended to take:

  • Estrogenic Supplements​​​
  • St.Johns Wort
  • Grapefruit Products

What foods should be avoided with Anastrozole?

When using Anastrozole medication (a type of medication), its best not to consume foods containing levels of phytoestrogens, like:

  • Flaxseed (linseed) Chickpeas (also known as Garbanzo beans)
  • Sesame seeds (commonly used in cooking and baking)
  • Grapefruit and Grapefruit juice (often enjoyed as part of a meal or drink)
  • Soy-based products such as Tofu (a meat substitute made from soybeans)
  • Soy milk (plant-based milk alternative) and Tempehm(fermented soybean product).

When to take Anastrozole with Testosterone Bodybuilding

In bodybuilding circles, Anastrozole is commonly used in conjunction with testosterone to regulate estrogen levels and testosterone intake.

  • The frequency of Anastrozole intake ranges from 1 to 3 times weekly based on individual reactions, with dosages typically falling between 0.5 mg and 1 mg per intake session.
  • Timing varies according to testosterone dosage and cycle but is usually spaced out evenly for consistent estrogen management.
  • It's recommended to seek advice from a healthcare provider for fine-tuning timing and dosage, guided by blood test results.

When to take Anastrozole

Anastrozole is typically consumed once a day. Can be taken with or, without food for results.

  • It is recommended to take it at the time every day for consistency in the treatment regimen.
  • The dosage and schedule may change depending on circumstances such as breast cancer or hormone regulation.
  • It is essential to always adhere to the guidance provided by your prescribing physician.

When to take Anastrozole with Testosterone

Anastrozole is usually paired with testosterone to manage estrogen levels in the body. It is often taken 1 to 3 times weekly as needed, based on the testosterone dose prescribed by a healthcare provider, for treatment after receiving testosterone injections.

Which has less side effects, Letrozole or Anastrozole

Letrozole and Anastrozo Have side effect profiles; however, Anastrozole might be more easily tolerated with fewer joint-related issues for some people. Overall, the side effect variances are usually minor and vary from person to person.

Which is better, Tamoxifen or Anastrozole

Anastrozole is commonly seen as more efficient than Tamoxifen for women in lowering the chances of breast cancer coming back, especially in hormone receptor-positive cancers; however, Tamoxifen is frequently prescribed for premenopausal women depending on the specific factors of each patient.

Why take Anastrozole with Testosterone

Anastrozole is often paired with testosterone to stop testosterone from turning into estrogen and lower the chances of experiencing side effects associated with estrogen, such as gynecomastia and retaining water.

Why does Anastrozole cause Joint Pain

Anastrozole causes joint discomfort by lowering estrogen levels, potentially causing inflammation and reduced joint lubrication.

Why do men take Anastrozole

Men use Anastrozole  to lower estrogen levels and avoid side effects such as gynecomastia and water retention when undergoing testosterone replacement therapy or using steroids to maintain testosterone levels.

Why would a man take Anastrozole

To regulate estrogen levels in men resulting from testosterone treatment or the use of steroids. Avoid side effects such as gynecomastia​while keeping hormones in check.

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