Doveran, Drotaverine Hcl

Doveran (Drotaverine HCl) is typically prescribed as a smooth muscle relaxant or an antispasmodic.

Doveran

Drotaverine Hcl

Doveran

10

Intas Pharma

tablet

80 mg

India

Doveran, Drotaverine Hcl

Introduction to Doveran (Drotaverine HCL)

Overview of Doveran as a Pharmaceutical Agent

Doveran is a medication containing Drotaverine HCL. It is known for effectively treating muscle spasms in different health conditions without causing drowsiness or dependence. It is widely appreciated for its long-lasting relief from pain caused by muscle contractions. 

History and Development of Drotaverine HCL

In the twentieth century, Drotaverine Hydrochloride was created to fulfill the demand for a powerful yet secure antispasmodic medication. Its chemical arrangement was fine-tuned to target muscle with minimal adverse effects, signifying a milestone in medical treatment.

Key Therapeutic Uses and Benefits

- Effective relief from gastrointestinal and biliary spasms.

- Reduction of menstrual pain in gynecological disorders.

- Improved urinary flow in patients with urological obstructions. Its versatility in treating a spectrum of conditions underscores its therapeutic importance.


Mechanism of Action as a Smooth Muscle Relaxant

When Doveran works its magic by blocking phosphodiesterase IV, an enzyme, for muscle movement. It triggers a rise in AMP levels that brings about the relaxation of smooth muscle tissues without causing widespread side effects, throughout the body.

Comparison to Similar Antispasmodic Drugs

Drotaverine provides a response and is safer than antispasmodics such as hyoscine or papaverine due to its different mode of action that does not involve anticholinergic effects. It is often the preferred option for patients who cannot take other medications.

Composition of Doveran

Active Ingredient: Drotaverine Hydrochloride

The main active ingredient in the drug is Drotaverine HCL, which plays a role in alleviating spasms.


Inactive Ingredients and Excipients

To enhance stability, lactose monohydrate is included in the formulation. Magnesium stearate is commonly used as a lubricant in applications. Microcrystalline cellulose is used to achieve a texture.

Available Forms and Strengths

Doveran is available in: - Oral tablets (40 mg, 80 mg) - Injectable form (2 ml ampoules containing 40 mg)

Drotaverine hydrochloride and mefenamic acid tablets

The combination of drotaverine hydrochloride and mefenamic acid is used to ease the symptoms of menstruation as well as colicky pains such as those affecting the ureter, bile duct, and intestines.

Drotaverine hydrochloride uses

Treatment of Smooth Muscle Spasms

Doveran is extensively utilized to manage spasms in the gastrointestinal and urinary tracts, ensuring quick symptom relief.

Relief in Gastrointestinal Disorders

It alleviates discomfort caused by:

- Irritable Bowel Syndrome (IBS)

- Colicky abdominal pain

- Biliary dyskinesia



Use in Gynecological Disorders

In gynecology, Doveran is prescribed for:

- Dysmenorrhea (painful menstruation)

- Endometriosis-related pain

- Post-surgical cramping

Application in Urinary Tract Disorders

It is effective in treating:

- Renal colic

- Ureteral stones

- Bladder spasms

Off-Label Uses of Doveran

Management of Migraines and Vascular Headaches

Even though it's not officially sanctioned for this use case yet, Doveran is occasionally used to help ease migraines due to its effects.

Use in Alleviating Labor Pains and Facilitating Cervical Dilation

During the childbirth process in obstetrics, this medicine helps to speed up labor by relaxing the muscles of the uterus and assisting in the dilation of the cervix.

Other Potential Off-Label Applications in Pediatric Care

- Management of functional abdominal pain in children.

- Relief from spasmodic constipation.

Drotaverine mechanism of action

Detailed Explanation of Its Action on Smooth Muscles

The Doveran medication helps prevent muscle movements by regulating calcium flow into cells and relieving spasms.

Role as a Selective Phosphodiesterase IV Inhibitor

This special system guarantees results by minimizing the chances of adverse reactions.

How It Improves Blood Flow and Relieves Spasm-Related Pain

By relaxing vascular smooth muscles, Doveran enhances blood flow to affected regions, reducing ischemic pain.

Timeframe for Onset of Action and Duration of Effect

The medication usually takes effect in 20 minutes. Provides relief that can last for, up to 6 hours.

Dosage and Administration of Doveran

- Tablets: 40-80 mg three times daily.

- Injections: 40 mg intramuscularly or intravenously, as required.

Dosage Adjustments for Specific Populations

- Elderly: Reduced doses to prevent accumulation.

- Children: Tailored dosing based on body weight.

Instructions for Oral, Intramuscular, and Intravenous Administration

Remember to swallow the tablets with water. Its best to take them after eating something. Intramuscular injections are typically reserved for situations that require relief. Receiving medication through an IV must be done under the care of a healthcare professional.

Best Practices for Safe Administration

Adherence to prescribed doses ensures efficacy while mitigating risks of side effects.

Important Precautions for Doveran Use

Necessary Monitoring During Treatment

Patients should be monitored for:

- Blood pressure fluctuations

- Unusual cardiac symptoms


Precautions for Patients with Liver or Kidney Impairments

Individuals with liver or kidney issues may require doses or different treatment options to effectively manage their condition.

Potential Impact on Ability to Drive or Operate Machinery

Drowsiness or dizziness may impair motor skills; caution is advised.

Avoidance of Alcohol and Specific Drug Combinations

Concurrent use with alcohol or sedatives can amplify side effects.

Warnings and Contraindications

Absolute Contraindications

- Severe hepatic or renal impairment.

- Known hypersensitivity to Drotaverine or any excipient.

Risk Factors for Adverse Reactions

Cautions for Use in Patients with Cardiovascular Disease

It is important to keep an eye on things because there could be problems related to blood vessel dilation.

Make sure not to use this with medications that impact heart rhythm. Not recommended when used together with phosphodiesterase inhibitors.


Side Effects of Doveran (Drotaverine HCL)

Overview of Potential Side Effects

Doveran, like any pharmaceutical agent, may induce side effects. While generally well-tolerated, certain reactions are possible, primarily when used in higher doses or over extended periods. These can vary in severity, frequency, and duration, with most being manageable and transient.

Frequency and Likelihood of Occurrence

- Common: Minor gastrointestinal and neurological symptoms.

- Uncommon: Dermatological and cardiovascular effects.

- Rare: Severe reactions, typically related to allergic responses or misuse.

Distinguishing Mild Side Effects from Serious Adverse Reactions

Mild side effects often resolve without intervention, including minor digestive discomfort or transient dizziness. In contrast, serious reactions such as arrhythmia or anaphylaxis necessitate prompt medical attention.

Common Side Effects of Doveran

Digestive Issues (Nausea, Vomiting, Constipation)

Doveran may induce digestive disturbances, particularly:

- Nausea

- Vomiting

- Constipation

These effects are typically mild and diminish with continued use or upon dose adjustment.


Neurological Effects (Dizziness, Headache, Sleep Disturbances)

Patients may occasionally report:

- Dizziness or light-headedness

- Headache

- Sleep irregularities

These effects are generally transient and may lessen over time.

Dermatological Reactions (Rash, Itching)

In rare instances, Doveran can cause mild dermatological reactions, including:

- Rash

- Itching

These symptoms are often manageable and resolve with antihistamines.

Interaction with Other Medications

Potential Drug Interactions and Synergistic Effects

Doveran may interact with various medications, leading to synergistic or antagonistic effects. Synergistic interactions can enhance its antispasmodic properties, while antagonistic effects may reduce efficacy.

Known Interactions with Analgesics, Antihypertensives, and Antibiotics

  • Analgesics: Possible increase in analgesic effect.
  • Antihypertensives: Potential for additive blood pressure-lowering effects.
  • Antibiotics: Certain antibiotics may interact, altering the absorption rate.

Recommendations on Avoiding Simultaneous Use with Specific Drugs

Avoid combining Doveran with drugs that depress the central nervous system or significantly impact blood pressure without medical supervision.

Impact on Blood Pressure and Cardiac Medications

The vasodilating effects of Doveran could impact the effectiveness of blood pressure and heart medications may require supervision.

Administration in Special Populations

Administration to Elderly Patients

Considerations for Dosage Adjustments and Monitoring

Elderly patients may require lower dosages to prevent accumulation and adverse reactions. Regular monitoring is advised due to possible heightened sensitivity.

Increased Risk of Side Effects and Drug Sensitivity

The elderly are more susceptible to side effects such as dizziness or hypotension. Adjustments and careful monitoring are crucial.

Drotaverine in pregnancy

Safety Profile During Pregnancy (FDA Category, if Applicable)

Doveran is typically prescribed during pregnancy only when benefits outweigh potential risks. Safety during the first trimester remains under-researched.

Risks Associated with Breastfeeding and Drug Excretion

Limited studies suggest minimal excretion into breast milk, but caution is recommended. Discussing risks with a healthcare provider is advisable.


Administration to Children

Pediatric Use, Safety, and Dosing Guidelines

In patients doctors typically approach Doveran use, with caution adjusting doses according to the childs age and weight.

Off-Label Considerations in Pediatric Care

In certain cases, Doveran may be prescribed off-label for pediatric use under strict medical supervision.

Handling Precautions for Doveran

Proper Handling and Storage of Different Forms (Tablets, Injections)

- Tablets: Store in original packaging, away from moisture.

- Injections: Keep refrigerated if required and away from light.

Guidelines for Healthcare Providers in Administering the Drug

Administer Doveran injections with sterile technique to prevent contamination. Always adhere to recommended dosage and preparation protocols.

Disposal Instructions for Unused or Expired Medication

Dispose of unused Doveran responsibly, avoiding environmental contamination. Return expired medication to a pharmacy for proper disposal.

Overdosage of Doveran: Signs, Symptoms, and Management

Symptoms and Signs of Doveran Overdose

Symptoms of overdose may include:

- Severe hypotension

- Bradycardia

- Respiratory depression

Emergency Response and Immediate Actions

Prompt; It is crucial to provide prompt and necessary care by offering support, for breathing and heart function as administering fluids through an IV to help maintain blood pressure stability.

Available Antidotes and Supportive Care Measures

Currently, no specific antidote exists. Symptomatic treatment remains the primary approach.

Long-Term Monitoring and Management Post-Overdose

After an overdose it's important to keep a watch, on the patients organ function and overall well being to ensure they're stable.

Storage Requirements for Doveran

Store Doveran, at room temperature between 15 to 25 degrees Celsius for optimal storage conditions; maintaining humidity levels is essential to avoid any degradation issues, in the product.

Proper Storage Away from Direct Sunlight and Moisture

Store tablets and ampoules in a dry, dark location to preserve potency.

Shelf Life of Tablets and Injectable Forms

Typically, Doveran tablets and injections have a shelf life of two years, provided they are stored correctly.

Guidelines for Patients on Storage at Home

Patients should keep Doveran in a safe place, out of reach of children, and away from extreme temperature fluctuations to ensure efficacy.

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Doveran, Drotaverine Hcl FAQ

Drotaverine hydrochloride which class of drug?

Drotaverine is a medication categorized under antispasmodics in the realm of pharmaceuticals.

What is drotaverine hydrochloride tablets used for?

Drotaverine hydrochloride is a medication that helps with pain relief and is used to treat smooth muscle spasms commonly found in conditions such as pain and abdominal discomfort caused by kidney or biliary stones and gastrointestinal colicky pain.

What is drotaverine hydrochloride tablet?

Drotaverine hydrochloride is a type of medication that acts as an antispasmodic and pain reliever. It is commonly used to treat and alleviate spasms in muscles, such as those experienced in pain or abdominal discomfort caused by conditions like kidney stones or gallstones and gastrointestinal colicky pain.

What is drotaverine hydrochloride?

Drotaverine is prescribed to alleviate pain associated with smooth muscle spasms, such as cramps and discomfort caused by kidney stones or gallstones, as well as gastrointestinal colic pain.

What is drotaverine hydrochloride used for?

Drotaverine hydrochloride is an antispasmodics medication that helps alleviate smooth muscle spasms and relieves pain.

How to use drotaverine hydrochloride?

Take this medication with or without food as per your preference. For adults, the recommended dose is 40 to 80 mg three times daily, though the dosage may differ based on needs. Children aged 1 to 6 should take 20 mg three to four times a day. Children over six years old can start with a dosage of 40 mg.

Can I take drotaverine hydrochloride?

Adult patients typically take 1 to 40 mg tablets three times a day, whereas children receive drotaverine doses based on their age and body weight.

What are drotaverine hydrochloride?

Drotaverine hydrochloride is a type of medication that acts as an antispasmodic and pain reliever. It is commonly prescribed to treat and alleviate smooth muscle spasms.

What is drotaverine hydrochloride used for?

Drotaverine is prescribed to alleviate pain caused by conditions such as cramps and kidney stones by targeting smooth muscle spasms in the body.

Can I take drotaverine for stomach pain?

Drotaverine is a type of medication that helps relieve pain caused by muscle spasms.

What time should I take Drotaverine?

For adults, the recommended dosage is 40 to 80 mg three times a day, which may vary based on needs and conditions. For children aged 2 to 5, it is advisable to take 20 mg three to four times as directed by the healthcare provider.

Is Drotaverine effective?

Drotaverine hydrochloride demonstrated an enhancement ( significant, at P < 0·01 level ) in the overall alleviation of abdominal discomfort.

Can you buy drotaverine over the counter?

Antispasmodics are commonly utilized for alleviating pain in situations as these drugs are considered safe and readily accessible without a prescription.

Is drotaverine an antibiotic?

No

What are the side effects of Drotaverine?

Possible gastrointestinal effects include nausea, digestive discomfort, or constipation, while rare nervous system effects may manifest as headaches, feelings of dizziness, and difficulty falling asleep.

Is Drotaverine anti-inflammatory?

The way mefenamic acid works is not entirely clear; however, it is known to possess inflammatory properties and can help with pain and fever reduction as a nonsteroidal anti-inflammatory drug (NSAID).

How to take Drotaverine hydrochloride?

For adults, you can take Drotaverine with food or as a tablet three times after eating, at a dosage of 40 to 80 mg per dose, depending on your condition.

Can I take Drotaverine with paracetamol?

Drotaverine plus Paracetamol is prescribed to alleviate discomfort. It combines Rotaverine and Paracetamol to provide relief from pain symptoms caused by smooth muscle spasms.

Why is Drotaverine used?

Drotaverine functions as a medication for alleviating pain and is commonly employed to ease discomfort arising from a range of conditions, such as muscle spasms, menstrual cramps, kidney stones, gallstones, irritable bowel syndrome, and headaches.

Is drotaverine safe for kidneys?

The common side effects included a drop in blood pressure and feelings of dizziness, and occasional bouts of nausea or vomiting.

Drotaverine hydrochloride which class of drug?

Drotaverine is a medication that falls under the category of drugs called antispasmodics.

What is drotaverine hydrochloride tablets used for?

Drotaverine hydrochloride is a medication that helps relieve pain by treating smooth muscle spasms commonly associated with conditions, such as pain and abdominal discomfort caused by kidney stones or gallstones and gastrointestinal colicky pain.

What is drotaverine hydrochloride tablet?

Drotaverine hydrochloride is a medication that works as an antispasmodiс drug and pain reliever to treat and alleviate smooth muscle spasms commonly found in conditions such as pain and abdominal discomfort caused by kidney or biliary stones and gastrointestinal colicky pain.

What is drotaverine hydrochloride?

Drotaverine is prescribed to alleviate pain caused by conditions such as cramps and gastrointestinal colic, as well as pain stemming from kidney and biliary stones.

What is drotaverine hydrochloride used for?

Drotaverine hydrochloride is a medication that helps relieve muscle pain and spasms. It is commonly used to treat and alleviate muscle spasms.

How to use drotaverine hydrochloride?

You can take it with or without a meal, as you prefer. For adults the recommended dosage is 40 to 80 mg three times daily. It may differ depending on the individual. Children between 1 and 5 years old should take 20 mg three to four times a day. Children above six years of age should begin with a dosage of 40 mg.

Can I take drotaverine hydrochloride?

Adult patients typically take 1 to 3 tablets of 40 mg in three doses daily. In children receiving drotaverine treatment, the dosage is determined based on their age and body weight.

What are drotaverine hydrochloride?

Drotaverine hydrochloride is an antispasmodic medication that works as a pain reliever. It is commonly used to help treat and alleviate muscle spasms.

What is drotaverine hydrochloride used for?

Drotaverine is prescribed to alleviate pain caused by conditions such as cramps and kidney or biliary stones that result in smooth muscle spasms in the tract.

Can I take drotaverine for stomach pain?

Drotaverine is a type of medicine that helps relieve pain caused by muscle spasms.

What time should I take Drotaverine?

For adults, the recommended dose is 40 to 80 mg three times daily (dosage may differ). Children between the ages of 3 and 7 can take 20 mg three to four times a day as directed.

Is Drotaverine effective?

Drotaverine hydrochloride was found to offer enhancements (with a significance of P < 0.01 ) in the overall alleviation of abdominal discomfort.

Can you buy drotaverine over the counter?

Antispasmodics are commonly utilized for alleviating pain in situations as they are considered safe and readily accessible without a prescription.

Is drotaverine an antibiotic?

No

What are the side effects of Drotaverine?

Potential gastrointestinal side effects include nausea and indigestion, as well as the possibility of constipation occurring as a result of use. Regarding effects on the system, users may experience occurrences of headaches, vertigo, dizziness, and insomnia, but these effects are considered rare.

Is Drotaverine anti-inflammatory?

Mefenic acid is classified as a nonsteroidal inflammatory drug (NSAID) exhibiting properties that reduce inflammation and relieve pain and fever symptoms, in the body by inhibiting prostanglandin synthesis pathways although the precise mechanism of its action remains not fully elucidated.

How to take Drotaverine hydrochloride?

Drotaverine is a pill that can be Taken with or without food. It is taken three times daily by adults at a dosage of 40 to 80 mg per dose, depending on health needs.

Can I take Drotaverine with paracetamol?

Drotaverine combined with Paracetamol is prescribed for stomach pain relief. This blend of medications eases discomfort and helps alleviate muscle spasms, with the anti-spasmodic properties of Rotaverine.

Why is Drotaverine used?

Drotaverine is a medication that helps to alleviate pain caused by ailments such as muscle spasms, menstrual cramps, kidney stones, gallstones, irritable bowel syndrome, and headaches.

Is drotaverine safe for kidneys?

The common side effects included a drop in blood pressure and feelings of dizziness, as well as the possibility of experiencing nausea or vomiting.

Drotaverine hydrochloride which class of drug?

Drotaverine is a medication categorized under antispasmodics in the field of pharmaceuticals.

What is drotaverine hydrochloride tablets used for?

Drotaverine hydrochloride is a medication that helps with muscle spasms and pain relief for conditions like cramps and abdominal discomfort caused by issues such as kidney stones or gallstones well, as colicky gastrointestinal pain.

What is drotaverine hydrochloride tablet?

Drotaverine hydrochloride is a medication categorized as an antispasmodic that works as a pain relief option for conditions involving muscle spasms, such as pain and abdominal discomfort caused by issues like kidney stones or gallstones along with gastrointestinal colicky pain.

What is drotaverine hydrochloride?

Drotaverine is commonly prescribed to alleviate types of pain caused by muscle spasms in the body, such as pain and colicky pain in the gastrointestinal tract or due to kidney or biliary stones.

What is drotaverine hydrochloride used for?

Drotaverine hydrochloride is a type of antispasmodiс medication that is commonly used as a pain relief remedy to alleviate and treat smooth muscle spasms.

How to use drotaverine hydrochloride?

Take this medication with or without meals as directed. For adults, the recommended dosage is 40 to 80 mg three times per day, although individual dosages may differ. For children aged 1 to 3 years, the suggested dose is 20 mg three to four times a day. Children aged six and above should begin with a 40 mg dose.

Can I take drotaverine hydrochloride?

Adult patients typically take 1 to 3 tablets of 40 mg each day in divided doses, while children are administered drotaverine in doses tailored to their age and body weight.

What are drotaverine hydrochloride?

Drotaverine hydrochloride is a medication known for alleviating pain by acting as an antispasmodic. It is commonly used to treat and provide relief from muscle spasms.

What is drotaverine hydrochloride used for?

Drotaverine is prescribed to alleviate types of pain caused by muscle spasms in the body, such as cramps, colicky pain in the gastrointestinal system, and discomfort from kidney or biliary stones.

Can I take drotaverine for stomach pain?

Drotaverine is a medication that helps alleviate pain caused by muscle spasms.

What time should I take Drotaverine?

For adults, the recommended dosage is 40 to 80 milligrams three times daily, although this may differ depending on needs or circumstances; whereas, for children aged 2 to 7, the suggested dose is 20 milligrams taken three to four times daily as directed by a healthcare provider or physician.

Is Drotaverine effective?

Drotaverine hydrochloride demonstrated an enhancement (p < 0,01 ) in alleviation of stomach discomfort.

Can you buy drotaverine over the counter?

Antispasmodics are commonly used to alleviate pain in situations since these medicines are considered safe and easily accessible without a prescription.

Is drotaverine an antibiotic?

No

What are the side effects of Drotaverine?

Potential gastrointestinal issues include feelings of nausea and indigestion, along with the possibility of experiencing constipation, while rare nervous system effects may manifest as headaches or dizziness, occasionally leading to insomnia.

Is Drotaverine anti-inflammatory?

Mefamic acid is a type of inflammatory drug that has properties to reduce inflammation and pain while also lowering fever levels through mechanisms that are not fully comprehended but may involve the inhibition of prostaglandin synthesis.

How to take Drotaverine hydrochloride?

Drotaverine can be consumed as a tablet either with or following meals up to three times daily in adults at a dosage of 40mg to 80mg per dose, depending on the individual's health condition.

Can I take Drotaverine with paracetamol?

Drotaverine + Paracetamol is prescribed for treating stomach pain as it combines Rotaverine and Paracetamol to alleviate discomfort caused by muscle spasms linked to muscles.

Why is Drotaverine used?

Drotaverine is a medication that helps with pain relief in cases such as muscle spasms and menstrual cramps as conditions like kidney stones and irritable bowel syndrome or headaches.

Is drotaverine safe for kidneys?

The common side effects observed included a drop in blood pressure, feelings of dizziness, and potential instances of nausea or vomiting.

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