Exelon

Exelon capsule is used for the treatment of dementia which is co-related with Alzheimer's and Parkinson's disease. Exelon capsule works to improve awareness and memory. Exelon capsule balances out the neurotransmitter activity in the brain.

Exelon

Rivastigmine hydrogen tartrate

Exelon

28

Novartis India

Capsule

1.5 mg 3.0 mg 4.5 mg 6.0 mg

India

Exelon

Introduction

What is Exelon?

Exelon, also called Rivastigmine, is a medication primarily used to treat Alzheimer's disease and Parkinsons' disease dementia. With the growing number of individuals worldwide, there is a higher occurrence of neurodegenerative disorders. This makes Exelon an essential medicine for managing these conditions.

Overview of its pharmacological classification

Exelon falls under a category of medications known as 'cholinesterase inhibitors from a perspective. These drugs work by blocking the breakdown of acetylcholine, a neurotransmitter responsible for memory, learning, and cognitive functions.

Uses of Exelon

Approved therapeutic indications

Exelon is a medication that is used to treat mild to moderate dementia caused by Alzheimer’s or Parkinson’s disease 1It works by improving the function of nerve cells in the brain and preventing the breakdown of a chemical that is important for the processes of memory, thinking, and reasoning 1Exelon is not a cure for Alzheimer’s or Parkinson’s disease 1.

Here is a reference that provides more information about Exelon:

  1. Drugs.com: This website provides information about the uses, dosage, side effects, and more of Exelon1.

Diseases and conditions treated by Exelon

Exelon is a medication that is mainly recommended for individuals with dementia associated with Alzheimer’s and Parkinson’s diseases1It has shown potential in addressing symptoms related to cognitive impairments1However, its primary goal is to improve abilities and alleviate behavioral symptoms in patients with dementia1.

Here is a reference that provides more information about Exelon:

  1. Drugs.com: This website provides information about the uses, dosage, side effects, and more of Exelon1.

How Exelon Works

Mechanism of action in the body

Exelon works by blocking the enzymes acetylcholinesterase and butyrylcholinesterase that are responsible for breaking down the neurotransmitter acetylcholine. This helps maintain levels of acetylcholine in the brain leading to improved neural communication and cognitive abilities.

Relevance in treating specific conditions

In conditions such as Alzheimer's and Parkinson's' disease dementia, there is a known lack of acetylcholine. Exelon helps by maintaining the levels of this neurotransmitter, which helps to lessen decline and reduce the appearance of behavioral symptoms linked to these illnesses.

Off-label Use

Explanation of what off-label use means

Off-label use is when a medication is prescribed for a condition, age group, dosage, or administration route that health agencies haven't officially approved. It's a practice that relies on evolving clinical experiences and emerging evidence.

Common off-label indications for Exelon

Exelon is a medication that is mainly recommended for individuals with dementia associated with Alzheimer’s and Parkinson’s diseases1It has shown potential in addressing symptoms related to cognitive impairments1However, its primary goal is to improve abilities and alleviate behavioral symptoms in patients with dementia1.

Here is a reference that provides more information about Exelon:

  1. Drugs.com: This website provides information about the uses, dosage, side effects, and more of Exelon1.

Scientific basis and studies supporting off-label use

Several reputable studies have documented the effects of Exelon in addressing advanced forms of Alzheimer's disease, even though it is officially approved for only mild to moderate stages. Additionally, initial trials suggest that Exelon may have advantages in managing Lewy body dementia, although further conclusive evidence is still being gathered.

Dosage and Administration

Standard dosing guidelines

Exelon is usually started at a dose to assess how well the patient can tolerate it and then gradually increased to reach the most effective therapeutic levels over weeks. Healthcare providers often emphasize the importance of following the prescribed dosages to ensure the medication works effectively and minimizes adverse effects.

Adjustments for specific populations

Certain groups of people, like those with liver or kidney problems, may need adjustments to their medication dosage. Older patients might also require a personalized approach to determining the correct dose.

Route of administration

Exelon comes in two forms: oral capsules and transdermal patches. When you take the form, it's recommended to do so with meals. On the other hand, the patch delivers a consistent release of medication when placed on the skin and is typically changed daily.

Tips for proper administration

To achieve the outcomes it is crucial to follow these instructions; Take the oral capsules along, with a meal. Apply the patch on areas of clean, dry skin that are free of hair. Rotate the sites where you apply the patch to avoid any skin irritation.

Composition

Active ingredients in Exelon

The main active ingredient in Exelon is Rivastigmine. This substance works by affecting the processes associated with memory and thinking, which contributes to its therapeutic effects.

Excipients and their roles

Excipients refer to the ingredients found in medications, which play various roles, such as enhancing stability and improving drug delivery. In the case of Exelon, careful selection of these excipients is made to ensure the medication's possible release, absorption, and stability.

Common Side Effects

Most frequently observed adverse reactions

  • Nausea
  • Vomiting
  • Diarrhea
  • Loss of appetite

Statistic on incidence and severity

Around 30% of individuals taking Exelon may encounter issues, with nausea being the most common. It's important to note that these side effects generally decrease as the body adjusts to the medication within a few weeks.

Serious Side Effects

Potentially life-threatening reactions

Although it is not everyday specific individuals may experience side effects such as; Irregular heart rhythms, Severe digestive problems resulting in dehydration, Aggravation of asthma, or chronic obstructive pulmonary disease (COPD)

Symptoms and signs to watch out for

It is crucial to identify symptoms such as rapid heartbeats, intense stomach pain, continuous vomiting, and difficulty breathing and promptly seek medical help.

Steps to take in the event of a serious side effect

If you experience adverse reactions stop taking the medication right away. It is essential to reach out to a healthcare professional. If symptoms worsen, seek immediate medical attention.

Interaction with Other Drugs

Common drugs that may interact with Exelon

Interactions between medications can impact the effectiveness of treatment or increase the likelihood of experiencing adverse side effects. Some drugs that have been found to interact with Exelon include medications with properties like Benztropine and Atropine beta-blockers such as Metoprolol, and specific antifungal agents, like Ketoconazole.

How to avoid harmful drug interactions

To ensure safety, keeping an up-to-date record of all medications, over-the-counter products, and supplements is essential. Regularly discussing this list with healthcare professionals is also crucial. Remember not to start or stop any medicine without consulting a professional beforehand.

Importance of informing healthcare providers about all medications

It is essential to provide healthcare professionals with information about medications. This transparency allows the practitioner to evaluate interactions between drugs, ensuring the safety and effectiveness of the medication regimen.

Warning and Contraindication

Absolute contraindications for Exelon use

Exelon, similar to medications, has certain situations where it should not be used. Patients who have a known allergy or sensitivity to Rivastigmine or any of the ingredients in Exelon should avoid using it.

Situations where Exelon should be used with caution

Exelon should be prescribed cautiously in patients with arrhythmias, active or past peptic ulcers, and respiratory conditions such as asthma or COPD.

Careful Administration

Guidance for populations with special considerations

Exelon's effects on the body may vary depending on groups of people. It is important to note that specific populations, those with liver or kidney conditions, require careful adjustments to the dosage and regular monitoring.

Monitoring parameters for therapy

Patients taking Exelon should have checkups, which include evaluations of their cognitive function, cardiac health, and gastrointestinal well-being.

Important Precautions

How to take Exelon safely and effectively

To ensure the results from your therapy, Always follow the recommended dosages as prescribed. Consult with a healthcare before making any changes or stopping the medication. Make sure to attend your scheduled follow-up appointments for monitoring.

What to avoid while on Exelon

Patients should refrain from drinking alcohol. Avoid operating heavy machinery if they feel dizzy or drowsy.

Administration to Specific Populations

Elderly: Adjustments and considerations for older adults

Elderly individuals might have a sensitivity to Exelon. It is usually recommended to start treatment with a dose and gradually increase it. Since older patients often take medications, it is essential to closely monitor for any adverse reactions.

Pregnant Women and Nursing Mothers: Safety profile and recommendations

There isn't information available about the effects of Exelon, during pregnancy so it should only be used if absolutely necessary. If you are breastfeeding, it's important to be cautious because Rivastigmine can be passed on through breast milk.

Children: Dosage, safety, and efficacy information

Exelons safety and effectiveness in children have not been extensively confirmed. Therefore, its usage, in this age group, is currently not recommended.

Overdosage

Symptoms of Exelon overdose

Taking doses than recommended can result in the following symptoms: Severe nausea and vomiting, Excessive salivation Bradycardia, which means a slower heart rate Respiratory depression.

Immediate steps to take and treatments available

If you suspect an overdose, it's crucial to seek medical assistance. Medical professionals will take actions such, as managing the airway and monitoring the heart. In cases of slow heart rate atropine may be given as an antidote.

Storage

Optimal storage conditions for Exelon

To ensure the effectiveness of Exelon, it is essential to store it correctly. Keep Exelon at room temperature, away from light and moisture. It is recommended to store Exelon patches in their pouches until you are ready to use them.

Shelf life and stability

It is recommended that patients do not use Exelon after it has expired. It is wise to dispose of any medication that looks discolored or shows signs of deterioration.

Handling Precautions

Safe handling and disposal of Exelon

To ensure safety, it is important to keep medications away from the reach of children and pets. When disposing of used Exelon patches, fold them in half with the sides together and discard them in a safe manner.

Considerations for healthcare providers and caregivers

Healthcare professionals and caregivers are advised to wear gloves when handling Exelon patches. It is also recommended to avoid touching the eyes and to wash hands after handling, even if gloves were used.

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