Sildenafil/ Lignocaine Cream

Vegah Cream is used for the treatment of impotence in men, Vegah Cream works by increasing and allowing the body's ability to maintain and erection during sexual intercourse.

Sildenafil/ Lignocaine Cream

Sildenafil/ Lignocaine

Vegah, Vforce

15 gm

Signature

Cream

Sildenafil 2% / Lignocaine 2%

India

Sildenafil/ Lignocaine Cream

1. Introduction

Overview of Sildenafil/Lignocaine Cream

Sildenafil/Lignocaine Cream is a cream that blends two ingredients, Sildenafil and Lignocaine to provide both vasodilatory and anesthetic effects. This cream is commonly used for its benefits, in different medical situations.

Historical Background and Development

The creation of Sildenafil/Lignocaine Cream was driven by the goal of improving treatment effects while reducing overall exposure to the body. Sildenafil, initially developed for heart conditions, became well known for its effectiveness in addressing dysfunction. Lignocaine, a trusted anesthetic with a long history of use in medical practices, has been a staple ingredient for many years. Bringing together these two components in a form marks notable progress in the field of medical treatments.

Importance in Medical Treatments

The importance of Sildenafil/Lignocaine Cream in treatments is immense. This cream offers targeted vasodilation and numbing effects, making it effective for issues such as erectile dysfunction and localized pain relief. Its dual benefits enhance recovery and decrease reliance on systemic drugs, thereby lowering the risk of side effects.

2. Composition

Active Ingredients: Sildenafil and Lignocaine

The cream has two active components: Sildenafil and Lignocaine.

  • Sildenafil works by blocking phosphodiesterase type 5 (PDE5) which helps improve blood circulation in areas.
  • Lignocaine acts as an anesthetic offering temporary numbness and pain relief.


Mechanism of Action for Each Component

Sildenafil functions by blocking the enzyme PDE5, resulting in a rise in cyclic guanosine (cGMP) levels. This action helps relax muscles and widen blood vessels, encouraging better blood circulation. On the other hand, Lignocaine works by obstructing sodium channels, hindering the transmission of nerve signals, leading to its numbing effect.

Formulation Details

The creation of Sildenafil/Lignocaine Cream requires blending these two substances in a stable cream base. This guarantees application and absorption when used on the skin. The cream is crafted to be non-oily, quick to absorb, and convenient for users, offering benefits along with comfort for the patient.

Sildenafil vs sildenafil citrate

Sildenafil, known as the component in Viagra (with the complete name being sildenafil citrate) is also available, without the brand name often referred to as "generic Viagra" or just "sildenafil." Since both medications contain the active ingredient (sildenafil), they function similarly within the body.

Tadalafil vs sildenafil

Sildenafil, known as Viagra, kicks in faster, showing effects within 30 to 60 minutes. Its impact lasts only 4 6 hours. On the hand, Tadalafil, also called Cialis, takes anywhere from 30 minutes to 2 hours to take effect but allows for erections lasting up to 36 hours. Both medications enhance erection firmness. It comes with relatively mild side effects. Studies show that Tadalafil is as effective as Sildenafil in treating dysfunction (ED). Men with ED seem to prefer Tadalafil over Sildenafil (50/100mg) in research possibly due to its longer lasting effects. Tadalafil might become the choice among ED patients over Sildenafil, among phosphodiesterase inhibitors.

Sildenafil vs vardenafil

Vardenafil, known as Levitra is considered to be 10 times more potent biochemically, than sildenafil. This means that a lower dosage of Vardenafil may be sufficient to help achieve an erection, which could lead to side effects. Selectivity refers to the drugs capability to bind specifically to the enzyme PDE 5 located in tissues.

Lignocaine vs lidocaine

Lidocaine once known as lignocaine is a type of anesthetic, from the amide class.

3. Uses

Primary Medical Uses of Sildenafil/Lignocaine Cream

Sildenafil/Lignocaine Cream is mainly used for its ability to widen blood vessels and numb sensations. It is commonly used in the field to address erectile dysfunction and offer localized pain relief for different medical procedures.

Treatment of Erectile Dysfunction

One popular application, for this cream involves addressing dysfunction. Sildenafil boosts blood circulation to the tissues to aid in achieving and sustaining an erection with Lignocaine potentially aiding in decreasing sensitivity and extending the duration.

Topical Anesthesia

The ointment works as a numbing agent on the skin. Its capability to induce localized numbness is beneficial for surgeries, cosmetic procedures and managing discomfort in conditions, like neuropathic pain.

Approved Indications by Regulatory Authorities

4. Off-label Uses

Exploration of Off-label Uses

Apart from its uses, researchers have also looked into other potential applications of Sildenafil/Lignocaine Cream. These involve situations where its ability to widen blood vessels and provide pain relief could have effects, for treatment.

Premature Ejaculation

A common alternative application involves using Lignocaine to help with ejaculation by numbing penile sensitivity and potentially delaying ejaculation.

Other Potential Therapeutic Uses

Other potential therapeutic uses include the management of chronic pain conditions, localized vascular issues, and as an adjunct in certain dermatological treatments.

Clinical Evidence Supporting Off-label Applications

Research studies and real-life stories have backed up these uses, showing the cream's flexibility. Ongoing investigations are revealing possible uses, expanding its range of benefits.

5. How It Works

Pharmacodynamics of Sildenafil

Sildenafil boosts blood circulation by blocking PDE5, which results in levels of cGMP. This action helps relax the muscle cells and widen the blood vessels, promoting better blood flow to the specific region.

How long does sildenafil stay in your system

Viagra, also known as sildenafil, is a medication prescribed for treating dysfunction (ED). It functions by easing the muscles and blood vessels in the penis to assist in attaining and sustaining erections. The effects of Viagra usually persist for a minimum of 4 hours with the possibility of staying in your body for up to 20 hours equivalent, to a full day.

what if sildenafil doesn't work

If sildenafil isn't effective for you, it could be due to the following reasons:

  • you might not have waited sufficiently after taking it before engaging in activity,
  • waited excessively long after taking it to engage in sexual activity, or
  • the dosage may not be adequate.

Pharmacodynamics of Lignocaine

Lidocaine functions by obstructing sodium channels in nerve cells, thereby preventing the transmission and propagation of nerve signals. This leads to a reduction in sensation and alleviation of pain, in the area.


Synergistic Effects of Combined Use

When Sildenafil and Lignocaine are used together, they work together to produce the desired effects. The widening of blood vessels caused by Sildenafil enhances the numbing effect of Lignocaine resulting in treatment advantages. This pairing is especially beneficial for situations that call for improved circulation and alleviation of pain simultaneously.

6. Dosage and Administration

The amount of Sildenafil/Lignocaine Cream to use differs based on the condition being addressed. When dealing with dysfunction its recommended to apply a specific quantity to the penile region whereas for topical anesthesia the dosage is determined by the area needing numbing.

Step-by-step Guide to Proper Application

It's important to apply the cream for the best outcomes. Here's what you should do

  • Begin by washing and drying the area where you'll apply the cream.
  • Then spread the recommended amount of cream evenly on that area.
  • Gently massage it in until its fully absorbed.
  • Lastly remember to wash your hands after applying to prevent any spreading.

How to apply lignocaine hydrochloride gel on anus

  • Remember to clean the area around your bottom, with soap and water then rinse and dry gently.
  • Carefully insert the applicator into your bottom release an amount of the medication inside and afterwards
  • clean the applicator by dismantling it and washing it with soap and water.

Adjustments for Special Populations

Special populations may need doses. The elderly might need amounts because of changes in how the drug moves through their bodies, and children should only use the cream with close medical supervision. Pregnant and breastfeeding mothers should seek advice, from healthcare providers before using it.

Can you take sildenafil daily

It's safe to use Sildenafil, a medication for dysfunction, up to the recommended maximum dose of 100mg daily as long as you don't have any existing health problems and aren't using other ED medications with it. You can take it consecutively for days or even every day without any concerns.

How much sildenafil is too much

Sildenafil tablets for treating dysfunction are available in various strengths ranging from 25mg to 100mg. Typically the recommended dose is 50mg as needed. It's important not to exceed one dose, per day. Depending on how it works for you, the dosage can be adjusted to either 100mg or 25mg.

7. Side Effects

Detailed Overview of Potential Side Effects

Sildenafil/Lignocaine Cream, similar to medications may cause side effects. These unwanted responses can vary in severity based on how each person reacts and how long the cream is used. It is important for healthcare professionals and patients to be aware of these side effects, in order to handle and reduce any harmful effects efficiently.

Common Side Effects

Typical side effects of Sildenafil/Lignocaine Cream are generally mild and temporary. They may consist of:

  • Redness and irritation in the area
  • Feeling of warmth or burning at the site of application
  • Slight headache
  • Dizziness
  • These symptoms usually go away on their own as the body gets used to the medication.

Rare but Serious Adverse Reactions

In some cases, certain severe side effects might arise. These could involve:

  • allergic responses marked by skin rash, itching, and swelling;
  • Persistent erection lasting over four hours (priapism);
  • Severe drop in blood pressure;
  • Cardiovascular incidents, like heart attack or stroke.
  • It is crucial to seek medical assistance if any of these serious adverse reactions occur.

8. Common Side Effects

List of Frequently Reported Side Effects

Some common side effects linked to Sildenafil/Lignocaine Cream are skin irritation where its applied, numbness or tingling headaches and dizziness.

These effects are usually mild. Don't typically necessitate stopping the treatment.

Management and Mitigation Strategies for Common Side Effects

To manage well, follow these tips:

  • Apply the cream on clean skin to minimize irritation.
  • Use the suggested amount to avoid overexposure.
  • Give your skin time to rest between applications.
  • Seek advice from a healthcare professional if you experience troublesome symptoms.

Patient Education on Recognizing and Addressing Common Side Effects

It is crucial to educate patients about the side effects.

  • Patients need to know how to recognize signs of skin irritation or allergic reactions,
  • When to seek advice for side effects, and
  • The significance of following prescribed usage instructions.
  • With this information patients can actively take control of managing their treatment.

9. Warning and Precautions

Important Warnings for Use

When using Sildenafil/Lignocaine Cream, it's essential to keep in mind key precautions:

  • Refrain from using the cream if you have a known allergy to any of its ingredients.
  • Avoid applying the cream on damaged or inflamed skin.
  • Be careful not to let the cream touch your eyes or sensitive mucous membranes.


Precautions to Take Before Starting Treatment

Prior to starting treatment with Sildenafil/Lignocaine Cream, it is important to take into account the following:

  • A medical background, including any allergies and medications currently being taken
  • A full physical assessment to identify any reasons for caution
  • Conversations about possible side effects and how to handle them

Special Considerations for Patients with Pre-existing Conditions

Patients with health issues, like cardiovascular disease, liver or kidney problems, and a history of priapism, require extra care and close monitoring to prevent any worsening of their conditions.

10. Contraindications

Absolute Contraindications

Patients should not use Sildenafil/Lignocaine Cream if they have a known allergy to Sildenafil, Lignocaine, or any other components in the product. It is also not recommended for those currently using nitrates or nitric oxide donors because it may lead to low blood pressure.

Relative Contraindications

Some conditions require consideration when using the cream, such as severe liver or kidney problems, uncontrolled high blood pressure, and a past history of stroke or heart attack.

Conditions Under Which the Cream Should Not Be Used

Avoid using the cream in the following situations:

  • If you have wounds or active skin infections in the area where it will be applied, or
  • when using topical treatments that could potentially interact adversely.

11. Interaction

Drug Interactions with Sildenafil/Lignocaine Cream

Interactions with drugs can greatly affect the effectiveness and safety of Sildenafil/Lignocaine Cream.

Interactions with Other Topical Treatments

When using this cream, it's important to avoid using topical treatments that could affect its effectiveness. It is recommended to consult with healthcare providers before combining it with skin treatments.

Interaction with Systemic Medications

When using Sildenafil/Lignocaine Cream it's important to be aware of interactions, with certain medications.

  • These may include drugs that could intensify the blood pressure lowering effects and CYP3A4 inhibitors that might raise Sildenafil levels leading to possible side effects.

12. Careful Administration

Guidelines for Careful Administration

When using Sildenafil/Lignocaine Cream, it's important to be cautious to ensure its effectiveness and safety.

Remember these tips:

  • Apply the cream on clean, dry skin,
  • use the recommended amount to prevent excessive use, and
  • always follow the advice given by healthcare professionals.

Monitoring and Follow-up Recommendations

It's important to keep an eye on patients who are using this cream.

  • Make sure to schedule appointments to check how well it's working and if there are any side effects.
  • Adjust the dosage according to how the patient's responding and watch out for any signs of negative reactions.

Adjustments for Patients with Liver or Kidney Impairment

Patients who have issues with their liver or kidneys may need to adjust their dosage. It is advised to begin with a dose to check their tolerance, keep a close watch for any signs of toxicity and regularly evaluate the functioning of their liver and kidneys throughout the treatment period.

13. Administration to Special Populations

Administration to Elderly

Special care must be taken when giving Sildenafil/Lignocaine Cream to patients. Because of the body changes that come with aging, it may be important to adjust the dosage to avoid any reactions. The way the liver and kidneys work can impact how the drug is processed and removed from the body so starting with doses and adjusting carefully is crucial.


Dosage Considerations for Elderly Patients

  • Commence with the dose that is deemed effective.
  • Increase the dosage gradually depending on how the body responds and tolerates it.
  • Keep a watch for any indications of absorption, into the system and potential side effects.

Monitoring and Management in Elderly Patients

It's important to monitor older patients to ensure the cream is working well and is safe for them. Regular checkups are necessary to catch any reactions early on. Monitoring blood pressure, kidney function, and liver function regularly is crucial to avoid any problems.

Administration to Pregnant Women and Nursing Mothers

Pregnant women and nursing mothers should carefully weigh the risks and benefits before using Sildenafil/Lignocaine Cream. Although applying it topically usually carries overall risks, it's crucial to assess its safety during pregnancy and breastfeeding.

Safety Profile During Pregnancy

  • There is no information available about the harmful effects of Sildenafil and Lignocaine on fetal development.
  • It is recommended to use these medications only if the advantages outweigh the risks involved.
  • Seeking advice from a healthcare professional is crucial in cases.

Risks Associated with Breastfeeding

Both Sildenafil and Lignocaine have the potential to pass into breast milk. It is important to evaluate the potential risks posed to the baby in comparison to the advantages for the mother. In cases where it is deemed necessary exploring alternative treatment options or possibly discontinuing breastfeeding should be taken into account.

Administration to Children

Using Sildenafil/Lignocaine Cream on children is usually not recommended unless specifically prescribed. The safety and effectiveness, in patients have not been fully determined so it's important to proceed with caution.

Safety and Efficacy in Pediatric Populations

  • Insufficient research has been conducted on the use of medications, in children.
  • There is a risk of the medication being absorbed into the body and causing harm.
  • It is advisable to administer the medication under close medical monitoring.

Special Precautions for Use in Children

If it is considered essential, the following measures should be implemented;

  • Administer the dosage as feasible.
  • Keep a watch for any negative reactions.
  • Maintain communication with caregivers regarding usage and monitoring.

14. Overdosage

Symptoms of Overdosage

Excessive use of Sildenafil/Lignocaine Cream can result in side effects.

  • Signs of this may include dizziness and fainting
  • prolonged numbness and tingling
  • respiratory depression 
  • cardiovascular issues, like low blood pressure.

Immediate Steps to Take in Case of Overdosage

In case of taking much act quickly:

  • Stop using the cream right away.
  • Wash off any leftover cream at the application site with water.
  • Get medical help.

Long-term Management and Treatment of Overdose Effects

Long-term care often includes providing support and treating symptoms. It is crucial to monitor vital signs, hydration levels, and the functioning of organs. In severe instances hospitalization might be necessary, for close monitoring and necessary treatments.

15. Storage

Proper Storage Conditions

Be sure to store the Sildenafil/Lignocaine Cream to maintain its effectiveness and safety.

  • Store it at room temperature away, from sunlight and moisture.
  • Always keep the cream closed when you're not using it, and
  • avoid freezing or exposing it to extreme temperatures.

Shelf Life and Stability Information

The package usually shows the expiration date for Sildenafil/Lignocaine Cream. It's important to follow this timeline for results:

  • Make sure to check the expiration dates before using it.
  • Avoid using the cream after its expiration date to prevent any decrease, in effectiveness and possible harm.

Guidelines for Disposal of Unused or Expired Cream

Make sure you dispose of any expired cream properly to avoid any accidental exposure or harm to the environment.

  • Follow the guidelines in your area for getting rid of medications.
  • Don't pour the cream down the toilet or sink.
  • If possible, return any leftovers.
  • Expired products to a pharmacy or a disposal program.

16. Handling Precautions

Safety Measures for Handling

It is crucial to handle Sildenafil/Lignocaine Cream to prevent accidental exposure;

  • if needed, gloves should be worn to avoid direct contact.
  • Remember to wash your hands after applying the cream and
  • keep it out of the reach of children and pets.

Avoidance of Contamination

To preserve the quality of the cream

  • make sure not to let the applicator tip touch any surfaces.
  • Always seal the container securely after each application.
  • Refrain from sharing the cream with others to avoid any contamination risks.

Instructions for Healthcare Providers and Patients

Healthcare professionals and patients alike should receive guidance on handling procedures, including clear directions for application and disposal. It is crucial to educate them about the dangers of mishandling and ensure that patients grasp the significance of adhering to prescribed protocols.

17. Important Precautions

Patient Education on the Correct Use of the Cream

It's crucial to educate patients about using Sildenafil/Lignocaine Cream for the best results.

  • Start by explaining the cream's purpose and advantages.
  • Then, give instructions on how to apply it.
  • Stress the significance of following the regimen diligently.

Recognizing and Responding to Adverse Reactions

Patients need to have an understanding of possible negative reactions and how to handle them.

  • They should be able to recognize severe side effects, know when to consult a doctor or stop using the medication, and have emergency contact details easily accessible.

Importance of Adhering to Prescribed Usage Guidelines

Following the recommended instructions is important to guarantee the cream's safety and efficacy.

  • Refrain from changing the dosage or frequency without seeking advice from a healthcare professional.
  • Ensure you finish the treatment course unless instructed otherwise.
  • It is essential to discuss the treatment plan with a healthcare provider to address any questions or make necessary adjustments.
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