Synvisc Injection

Synvisc Injection is used for the treatment of osteoarthritis mainly in the knee. Synvisc Injection works to lubricate the joint providing pain relief.

Synvisc

Hyaluronic Acid

Synvisc

2ml x 3

Genzyme

Injection

8 mg/mL

India

Out of Stock.

Synvisc Injection

I. Introduction to Synvisc Injection

Overview of Synvisc and its Uses

Synvisc Injection is a product based on acid mainly utilized for treating knee osteoarthritis symptoms; it aims to offer lasting relief by lubricating the pain and swelling associated with the condition. It works as an alternative, to the bodys fluid which may be reduced in individuals suffering from osteoarthritis. The main goal of Synvisc is to enhance movement and alleviate the pain resulting from degeneration, particularly in the knee area.

History and Development of Synvisc

Synvisc was created as a progression, in viscosupplementation therapy to improve the qualities of fluid functionally restored by treatment methods. It was introduced in the 1990s following testing to verify its effectiveness and safety standards. The creation of Synvisc was driven by a growing demand for therapies targeting the impact of osteoarthritis—a condition associated with rigidity and discomfort.

General Benefits and Indications

Synvisc is primarily indicated for the management of knee osteoarthritis. By replenishing the synovial fluid, it enhances lubrication, absorbs shock, and facilitates smoother joint movement. This leads to substantial improvements in pain management, reducing the need for oral medications and providing a more targeted approach. It is often used in patients who have not responded well to other treatment options such as physical therapy or oral pain relievers.

The Role of Synvisc in Joint Health

The primary function of Synvisc in joint health is its ability to restore the viscous properties of synovial fluid. The injection promotes joint lubrication, reduces bone friction, and alleviates pain. This is particularly vital for patients with osteoarthritis, where the natural fluid in the joints deteriorates, leading to increased friction and discomfort. By enhancing fluid properties, Synvisc helps protect the cartilage and supports the overall health of the joint.

II. Uses of Synvisc Injection

Primary Indications for Synvisc

Synvisc is frequently employed to address knee osteoporosis as a form of viscosupplementation treatment that offers enduring alleviation from symptoms to help individuals restore their ability to move freely and improve their quality of life.

Osteoarthritis Management

OA is a condition that causes the deterioration of cartilage and commonly impacts weight-bearing joints such as the knees. Synvisc injections are vital in treating OA as they help lubricate and cushion the joints to alleviate pain and swelling. This treatment is especially beneficial for individuals who continue to have symptoms after trying NSAIDs or physical therapy.


Pain Relief in Knee Osteoarthritis

Osteoporosis in the knee can greatly impact tasks because of pain and swelling experienced by individuals suffering from it. Synvisc injections for pain relief and enhancing joint mobility functions effectively improve the quality of life for those with knee osteoporosis. These injections reduce bone friction between joints which leads to decreased pain symptoms and allow for movements while performing activities.


Synvisc as a Joint Lubricant

Synvisc is a lubricant that effectively replicates the natural synovial fluid in healthy joints. Enhancing this fluid's presence in the joints, boosts their shock-absorbing abilities, easing bone pressure and providing pain relief. The improved lubrication also plays a role in averting cartilage harm thus promoting sustained joint well being, over time.


Off-label Uses of Synvisc

Synvisc is mostly utilized for treating knee osteaoarthritis; however it has also been investigated for, off label applications.

Potential Benefits in Other Types of Arthritis

Synvisc has displayed potential in treating types of arthritis like rheumatoid arthritis and osteoporosis in the hip area. Although it hasn't received FDA approval, for these uses yet some healthcare providers utilize Synvisc as a therapy to enhance flexibility and decrease inflammation.


Off-label Use for Temporomandibular Joint Disorders (TMJ)

Temporomandibular joint disorders (TMJs) characterized by jaw pain and discomfort may be alleviated by the use of Synvisc off-label to lubricate the joints and alleviate pain; however, further research is required to ascertain its effectiveness, in the run, for this condition.

Use in Other Joint Conditions (Shoulder, Elbow, etc.)

Synvisc has also been used in ways to address arthritis in joints, like the shoulder and wrist, besides the knees, for which it was initially intended for treatment purposes when traditional methods prove ineffective or when patients opt for invasive options.

III. How Synvisc Works

Mechanism of Action

Synvisc works by imitating the fluid to help joints move smoothly and reduce pain and inflammation by acting as a lubricant, between bones and restoring the joints function through increased fluid viscosity.

Role of Hyaluronic Acid in Joint Lubrication

The main component in Synvisc is acid, which is found naturally in fluid, where it helps improve the joint's lubrication and shock absorption abilities, leading to smoother movement and reducing cartilage wear and tear, which helps the joint handle pressure and movement better.

Effect on Cartilage and Synovial Fluid

Synvisc injections aid in safeguarding the cartilage within the joint by lessening the friction that causes cartilage deterioration. Through enhancing the volume and thickness of fluid to offer improved cushioning g effects on the joints and lessening stress on the cartillage results in a slowdown of osteoporosis progression and a decrease in discomfort over time.


Impact on Inflammation and Joint Pain Relief

One of the benefits of Synvisc is its capacity to decrease inflammation significantly, which contributes to its effectiveness in restoring joint function and enhancing the patient's quality of life by easing swelling and pain over time to improve mobility as well.

IV. Synvisc dosage and Administration

Standard Dosing for Knee Osteoarthritis

In treating knee osteoporosis through injections, patients usually have a schedule where they get injected once a week for three to five weeks, depending on how serious it is what the doctor suggests.


Frequency and Duration of Treatment

The number of treatments and how they last can differ depending on the patient's situation, with some people finding it helpful to have follow-up treatments every six months or even longer periods of time, between them depending on how they initially respond to the injections and their overall joint health status.

Adjustments for Different Conditions and Patient Needs

Patients with forms of arthritis or joint problems, may require customized adjustments to their dosage and treatment schedule based on factors such as age and overall health status and the seriousness of their symptoms taken into account by physicians when devising a care plan.

Synvisc injection procedure (Injection Site and Procedure)

Synvisc injections are typically administered directly into the knee joint. The procedure is minimally invasive, usually performed in an outpatient setting. An experienced healthcare provider will clean the area, apply a local anesthetic if necessary, and inject the solution into the joint space. Proper technique is critical to minimize discomfort and ensure the effectiveness of the treatment.

V. Composition of Synvisc Injection

Synvisc injection ingredients and Active Components

Synvisc mainly consists of hyaluronic acid, which is a natural component present in the synovial fluid of the body's joints, along with other additives like sodium chloride to maintain its efficacy and durability over time.


Synvisc generic

Synvisc, also referred to as Synvisc One and known by its name Hylan G F 20, is an injection used for viscosupplementation purposes.

Role of Hyaluronan in the Formulation

Hyaluronan acts as a component that boosts the thickness and lubrication of fluid by imitating the functions of natural synovial fluid crucial for keeping joints moving smoothly.

Comparison with Other Hyaluronic Acid Injections

Synvisc is unique in its composition, featuring an amount of acid compared to other hyaluronic acid injections that may have different concentrations and may not offer the same level of effectiveness in treating severe osteoarthritis symptoms. Synviscs sophisticated formula enables it to deliver lasting relief and improved joint safeguarding.

Durolane vs synvisc

Durolane and Synvisc are both types of acid injections commonly employed to alleviate discomfort caused by osteoarthritis. These treatments involve replacing the body fluid with either synthetic or chicken-derived hyaluronic acid to alleviate pain and enhance mobility. Unlike Durolane, which demands an injection session for treatment completion, Synvisc might necessitate multiple injections up to five times for full effect.

Euflexxa vs synvisc

The Euflexxa treatment can alleviate pain for a duration of around six months, while Synvisc typically offers relief lasting between eight to 1 month after the injection.

Synvisc vs cortisone

Synvisc serves as a gel that provides lubrication to the joints whereas cortisone acts as a steroid that helps in reducing inflammation.

Orthovisc vs synvisc

Orthovisc is made through the fermentation process. Synvisc comes from a bird source origin. Orthovisc requires injections over a three-week period, whereas Synvisc One is administered once.

Monovisc vs synvisc

Monovisc is an injection containing weight hyaluronate that enhances the lubricating qualities of the fluid in the knee joint, while Synvisc is a combination of liquid and gel that acts as a buffer between the knee joint bones.

Zilretta vs synvisc

Zilretta is an injection containing corticosteroid that helps decrease inflammation in the body. On the hand Synvisc is an injection, with acid that replenishes lost fluid in the joints.

Hyalgan vs synvisc

Hyalgan is typically administered in five injections. On the hand Synvisc is usually administered over three injections; however some variations only involve a single injection.

VI. Synvisc side effects

Overview of Side Effects

Though Synvisc injections are usually well received by patients without any issues reported far, there might still be some instances where patients could encounter mild and short-term side effects, which usually resolve by themselves in the majority of cases; nonetheless, patients should always remain vigilant, about possible reactions and consult a healthcare professional if necessary.

Common Side Effects

Common side effects often include pain, swelling, or redness where the injection was given. These reactions typically go away within a couple of days. In some cases, patients might also feel headaches, dizziness, or minor digestive problems.

Rare or Severe Side Effects

In some instances, serious adverse effects could consist of an infection at the area of the injection, allergic responses, or increased discomfort. It is essential to seek assistance in these situations to avoid any further complications.


What to Do in Case of Side Effects

If you encounter any long-lasting side effects following a Synvisc injection treatment session, it's crucial to reach out to your healthcare provider. Typically these side effects can be controlled with the care or, by stopping the therapy if needed.

VIII. Warning and Precautions

Safety Concerns and Adverse Reactions

Although Synvisc injections offer significant benefits for joint health, safety must always be considered. While most patients experience minimal issues, some may encounter side effects such as pain at the injection site, redness, or swelling. These mild reactions typically subside within a short period. However, more severe reactions, including allergic responses or signs of infection, require immediate medical attention.

Risks of Injection-Related Infections

Any injection carries a risk of infection, and Synvisc is no exception. Although rare, infection at the injection site can occur, manifesting as increased pain, redness, or warmth. Proper sterilization of the injection site is crucial to reduce the risk. If an infection is suspected, patients should seek prompt medical attention to prevent complications.

Monitoring for Allergic Reactions

In some instances, patients may experience an allergic reaction to Synvisc. Symptoms can range from mild itching and rash to more severe reactions such as difficulty breathing or swelling of the face. It is important for healthcare providers to monitor patients closely following the injection for any signs of hypersensitivity. Immediate intervention is required for severe reactions to ensure patient safety.

Risks Associated with Overuse or Repeated Injections

Regularly administering doses of Synvisc over a prolonged period could heighten the chances of experiencing complications. Unintended side effects such as inflammation or alterations in the membrane may arise from excessive use of Synvisc, despite its overall safety, for extended durations. Healthcare professionals ought to monitor the patients status and review the efficacy of treatment to mitigate any avoidable risks.


Synvisc alternatives

Here are some injections containing acid that can provide relief, for knee pain and joint discomfort;

1. Hyalgan

2. Durolane

3. Euflexxa, a similar in structure to knee joint fluid

4. Orthovisc, a viscosupplement, with a structure to knee joint fluid

5. Supartz, aiding in pain relief

6. Monovisc

7. Gel One, a single use

8. Zilretta

9. Hymovic

IX. Contraindications for Synvisc Injection

Patients with Hypersensitivity to Components of Synvisc

It is important to avoid giving Synvisc to people who are allergic to acid or any of the ingredients in it and to be aware of any past allergic reactions to Synvisc or similar products before starting treatment. Additionally if patients show signs of sensitivity, like hives or swelling they should steer clear of this treatment option.

Contraindicated for Patients with Active Infections or Skin Diseases at the Injection Site

Patients should avoid getting Synvisc injections if they have any existing infections in the area where the injection will be given since it could make the infection worse by introducing Synvisc into a weakened joint or skin region. It's important to treat any signs of infection or skin problems before giving a Synvisc injection.

Patients with Bleeding Disorders or Compromised Immune Systems

Patients who have conditions like hemophilia or weakened immune systems are advised to steer off receiving Synvisc injections because of the heightened chances of experiencing bleeding or infection issues linked to it. The crucial step is to seek advice from a healthcare to ascertain if Synvisc is suitable under these circumstances.

X. Careful Administration and Important Precautions

Pre-Treatment Evaluation for Suitability

Prior to giving Synvisc injections to a patient, it's crucial to assess their well-being and medical background. Conducting an evaluation helps confirm if the treatment is appropriate for the patient's state. Doctors need to consider aspects like health status, past therapies, and any underlying medical conditions that might impact the results.

Special Considerations for Patients with Diabetes, Heart Conditions, or Kidney Problems

Some health conditions may need attention before getting Synvisc injections. People, with diabetes might need changes to their treatment because they are prone to problems. Similarly, those with heart problems or kidney disorders should be closely watched during the treatment as it could impact how their bodies react to the injection.

Need for Regular Follow-Up Care and Assessments

It's important to keep up with checkups to make sure that Synvisc injections are working well and to watch out for any reactions from them. This helps doctors make any needed changes, to the treatment plan so the results are the best they can be. Risks are kept low.

XII. Administration to Elderly Patients

Adjustments in Dosage or Treatment Frequency for Older Adults

Elderly individuals may need changes in the dosage or timing of Synvisc injections as their bodies may react differently to the treatment because of age-related alterations in structure or overall health condition. It's crucial to customize the treatment approach according to each person's requirements and health condition.

Specific Considerations for Elderly Individuals with Joint Conditions

As people get older and suffer from conditions like osteoarthritis or other joint issues, they may notice wear and tear happening in their joints. Utilizing Synvisc injections can provide relief from pain and enhance movement. However, it is crucial to keep an eye to ensure that no complications arise, such as infections or injuries from overuse. It's important to have check ups to track progress and make any changes, to the treatment plan..

Monitoring for Increased Risk of Side Effects

Elderly individuals could face an increased likelihood of encountering reactions to Synvisc such, as swelling in the joints or allergic responses, so it's crucial for healthcare professionals to carefully observe them throughout and after the treatment to promptly identify any impacts.

XIII. Administration to Pregnant Women and Nursing Mothers

Safety of Synvisc Use During Pregnancy

The safety of Synvisc has not been confirmed for use during pregnancy; therefore, it is usually advised against for women's treatment by healthcare professionals who must weigh the risks and benefits before prescribing Synvisc to a patient and should consider exploring other treatment options where available.


Potential Risks and Benefits for Pregnant Women

Pregnant women dealing with osteoporosis or joint discomfort might find some relief with Synvisc. Its crucial to weigh the risks for both the mother and the unborn baby first before deciding on treatment options.

Considerations for Breastfeeding Mothers

There is insufficient data on the transfer of Synvisc into breast milk. Nursing mothers should exercise caution when considering Synvisc injections. If treatment is deemed necessary, healthcare providers may advise taking appropriate precautions, including temporarily discontinuing breastfeeding.

XIV. Administration to Children

Safety and Efficacy in Pediatric Patients

Synvisc is generally not advised for use in children because there is information on its safety and effectiveness in pediatric patients. While there are treatments for joint issues, in children Synvisc should only be contemplated in rare instances under close medical monitoring.

For children with joint issues, treatment typically focuses on non-invasive methods, such as physical therapy, anti-inflammatory medications, or splints. In rare cases, a physician may recommend Synvisc as a treatment option, but this should be done with caution, considering the child's specific health needs.

Lack of Sufficient Data in Pediatric Populations

Limited data on how Synvisc affects patients due to the lack of clinical trials involving children leads to the general avoidance of its use in this age group; safer alternatives should be considered as a priority whenever feasible.

XV. Overdose of Synvisc Injection

Signs and Symptoms of an Overdose

It is highly improbable to overdose on Synvisc if you adhere to the prescribed dosage instructions meticulously; if an excessive dose is administered, signs of overdose might manifest as significant swelling or intense pain in the treated joint area. It is recommended to seek advice should any of these symptoms arise.

Treatment Protocols for Overdose

In the event of an overdose situation treatment usually includes providing care and managing symptoms. The medical professional might recommend using ice packs, inflammatory drugs (NSAIDs), or other methods to address swelling and discomfort.

Importance of Adhering to Prescribed Dosages

To avoid the dangers linked to taking too much medication at once, it's crucial to stick to the recommended dose and treatment plan as directed by your healthcare provider. Make sure to follow your healthcare provider's guidance and refrain from making any changes to the dosage without consulting a professional.

XVI. Handling Precautions for Synvisc Injection

Proper Storage and Transportation of Synvisc Vials

Make sure to store Synvisc in a dry spot that's shielded from sunlight to keep it effective as intended. To maintain the product's integrity while moving it around, you should use containers to protect it from temperatures.

Guidelines for Handling During the Injection Process

In the process of administering an injection it is crucial to adhere to practices to avoid any contamination issues. The medical professional needs to guarantee the preparation of the injection site and sterilization of all tools used in the procedure. Proper care in handling guarantees the safety and efficacy of the treatment.

Preventing Contamination and Ensuring Product Efficacy

To ensure the product’s efficacy, Synvisc should never be used if the vial is damaged or if it shows signs of contamination. Healthcare providers should visually inspect the vial for any abnormalities before administering the injection. Any concerns regarding the integrity of the product should lead to its disposal and replacement.

Synvisc Injection FAQ

What is Synvisc used for?

Medications are prescribed to help manage knee pain caused by osteoarthritis for patients who haven't found relief through drug treatments and basic pain relievers like acetaminophen.

How long do Synvisc injections last?

The medication typically remains effective for 4 to 5 months on average.

Is Synvisc the same as hyaluronic acid?

Hyalgan and Synvisc are both types of acid injections; however they differ in their administration schedules. Hyalgan typically requires five injections, whereas Synvisc is administered over three weekly injections.

Will Synvisc help bone on bone?

Once the cartilage wears away and there is bone on-bone contact, Synvisc and similar treatments may not be as effective.

How successful is SYNVISC?

The research indicated that individuals who were administered Synvisc One experienced reduced knee pain from osteoarthritis for a span of six months and reported feeling considerably improved compared to the control group given saline solution.

How many injections are needed for SYNVISC?

Synvisc is given through a shot into the weekly with a one-week gap between each of the three injections.

Can you walk after Synvisc injection?

It's advised to avoid engaging in activities involving your knee for 48 hours, but you can still carry out regular tasks, like walking.

Is SYNVISC-ONE a steroid?

No

Is SYNVISC FDA approved?

Yes

How long does SYNVISC take to work?

For a couple of days following the injection, focus on tasks and activities only. You might experience pain relief in the days itself; however it could take around six weeks to notice any significant improvement.

Who is a candidate for SYNVISC?

Synvisc One is intended for individuals suffering from knee osteoporosis who have not found pain relief through changes or over-the-counter painkillers.

What is the generic for SYNVISC?

Hylan G-F 20

How many times can Synvisc be given?

3

What is an alternative to Synvisc?

Meloxicam or Celebrex (celecoxib)

Which is better PRP or Synvisc?

In some cases, cortisone and Synvisc One injections tend to bring relief to the pain. On the other hand, PRPs work by triggering your body's natural healing process. It might take a bit longer to notice improvements in pain and other symptoms after the treatment.

When was Synvisc FDA approved?

August 8, 1997

How long does Synvisc last?

Up to 6 months

Does Synvisc have side effects?

Symptoms of knee trouble may include pain, swelling, warmth, redness, or fluid accumulation in or around the knee joint.

How do I know if Synvisc is working?

Following the injection of Synvisc One, numerous individuals reported feeling relief from pain for one month.

Is Synvisc good for knees?

Yes

How quickly does Synvisc work?

Synvisc One can alleviate knee pain caused by osteoarthritis for a period of about half a year, on average. It's important to note that individual responses vary; however a research study indicated that patients began to feel relief one month post the injection administration.

What are the benefits of Synvisc?

SYNVISC offers relief from pain to individuals at every level of osteoarthritis (OA), whether it's mild or stages of the condition. In a research investigation involving patients with OA in the knee that spanned from Grade 1 (considered OA symptoms) all the way to Grade 4 (indicating OA symptoms) individuals in each group reported feeling improved significantly after undergoing treatment, with SYNVISC.

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