Amlodipine / Benazepril

Amplodipine/Benazepril treats hypertension in individuals not sufficiently controlled on monotherapy with either agent. It relaxes blood vessels so blood can flow more easily.

Generic Lotrel

Amlodipine/ Benazepril

Amace BP

30

Systopic Laboratories

Tablet

Amlodipine 5 mg / Benazepril 10 mg

India

Out of Stock.

Amlodipine / Benazepril

Introduction

Overview of Amlodipine and Benazepril:

Amlodipine and Benzoatepril work effectively in the medical field, with each bringing its unique strengths to help lower high blood pressure. Amlodipine works as a calcium channel blocker, easing blood vessel constriction, while Benzoatepril, an ACE inhibitor, targets the angiotensin-converting enzyme to regulate blood pressure.

Purpose and Scope of the Medication:

This medicine is mainly given to treat blood pressure, which if not managed properly can lead to serious heart problems, like strokes and heart attacks. It also helps enhance heart health, reducing the risk of health issues linked to high blood pressure levels.

benazepril for dogs

Benazepril is commonly recommended for dogs and cats to manage heart failure, hypertension and different kidney ailments. These medications improve blood circulation. Are frequently combined with other heart treatments to enhance your pets quality of life.

Composition and Properties

Active Ingredients and Their Functions:

Amlodipine and Benazepril work together to create a combined effect. Amlodipine blocks calcium ions that play a role, in the heart and blood vessels contraction processes while Benazepril hinders the production of angiotensin II resulting in vasodilation.


Formulation Details:

The medication is offered in capsule form combining these ingredients in strengths to provide customized treatment choices that suit each patients specific needs depending on their medical history.

amlodipine valsartan

When one medication isn't sufficient to reduce your blood pressure, doctors may prescribe a combination of amlodipine and valsartan. Additionally this combination can be the treatment if your doctor determines that multiple blood pressure medications are necessary.

amlodipine olmesartan

Amlodipine and olmesartan make up a medication mix that can be taken by itself or alongside drugs to manage high blood pressure, also known as hypertension. High blood pressure can place strain on the heart and blood vessels. Prolonged high blood pressure could potentially lead to the functioning of the heart and arteries over time.

losartan vs amlodipine

Amlodipine showed results compared to losartan in lowering patients' 24-hour ambulatory blood pressure during the consistent sampling period. The rise in blood pressure over a 24-hour period while off the medication was an average of 6±2/2±1 mm Hg (P<0.0001) for those on amlodipine. 3±2/2±1 mm Hg (P<0.0001) for those, on losartan.

benazepril vs lisinopril

Zestril, also known as Lisinopril is a tablet meant to be taken once a day. It can also be found in form. Potential side effects of this drug may include coughing, feeling dizzy and experiencing headaches. Lotensin or Benazepril is often recommended as the treatment, for reducing high blood pressure levels.

Uses of Amlodipine / Benazepril

Indicated Uses in Hypertension:

Amlodipine / Benazepril is commonly used to treat blood pressure when a single treatment is not effective enough to manage blood pressure levels as desired.

Benefits in Cardiovascular Disease Management:

Taking Amlodipine / Benazepril regularly has proven to lower the dangers linked to prolonged hypertension, such as heart attacks, strokes, and heart failure.

Off-Label Uses

Exploration of Non-Approved Indications:

Amlodipine/Benazepril is sometimes recommended by healthcare professionals for ailments like kidney disease and migraine prevention apart from its authorized purposes.

Clinical Studies and Evidential Support:

Numerous clinical studies highlight the flexibility of this combined treatment showing its effectiveness and safety, in a variety of standard uses.

How It Works (Mechanism of Action)

Pharmacodynamics of Amlodipine:

Amlodipine works by blocking the entry of calcium ions through the L type calcium channels in the muscle surrounding blood vessels leading to widening of blood vessels and reduced resistance, in the vascular system.


Pharmacodynamics of Benazepril:

Benazepril helps blood pressure by affecting the renin-angiotensin aldosterone system. It works by decreasing the levels of angiotensin II, which leads to constriction in blood vessels and reduced fluid retention.

Synergistic Effects on Blood Pressure:

These methods work together to lower blood pressure, surpassing the effects of each component on its own.

Amlodipine half-life

Amlodipine, which has a life of 30 to 50 hours offers the advantage of being taken once a day unlike shorter acting options such, as nifedipine. The FDA approved this medication as amlodipine besylate in 1987. It has since become an essential part of treating hypertension and associated illnesses.

Dosage and Administration

Most adults begin by taking one capsule each day, which may be changed depending on the patient's condition.

Modifications in Dosage Based on Condition:

Adjustments to the dosage may be made based on kidney function. Feedback is from monitoring blood pressure over time.

Methods of Administration:

Remember to take the capsules by mouth either with or, without food and make sure to take them at the time every day for consistent therapeutic benefits.

best time to take amlodipine

It doesn't really make a difference whether you take amlodipine in the morning or evening. Its recommended to take it consistently at the same time each day ideally when you're most likely to remember to maintain steady blood levels and ensure effectiveness.

Administration to Specific Populations

Elderly Patients: Adjustments and Considerations:

Elderly patients should be closely. May need lower initial doses because they are more likely to have kidney issues.


Pregnant Women and Nursing Mothers: Safety and Guidelines:

It's not safe to take this medication during pregnancy because it could harm the baby. Nursing mothers should also steer clear of it to avoid passing any risks to their infants.

Pediatric Use: Age-Specific Dosages and Precautions:

When it comes to kids, the safety and effectiveness considerations differ, It's important to tailor the approach according to their age and weight under the close supervision of a pediatrician.

amlodipine nursing considerations

Before starting the treatment make sure to check the patients liver and kidney functions blood pressure and heart rate. If the systolic blood pressure goes down to 90mm Hg during amlodipine treatment stop the medication. Get in touch, with the doctor promptly.

Side Effects

Common Side Effects:

Amlodipine/Benazepril is usually well received. Some people might encounter mild to moderate side effects, like:

  • Feeling dizzy
  • Having a headache
  • Swelling
  • Tiredness
  • Nausea

amlodipine side effects weight gain

Amlodipine may lead to an increase in weight. While this side effect wasn't frequently mentioned in amlodipine trials, it is still possible. It's worth mentioning that amlodipine can result in swelling in the ankles or legs a known side effect of the medication, which could contribute to weight gain.


Potential Severe Reactions:

In cases, specific serious side effects require prompt medical intervention, such as:

  • Swelling in deeper skin layers known as angioedema resulting from fluid accumulation
  • Low blood pressure, particularly severe in individuals with advanced heart failure
  • Liver failure accompanied by yellowing of the skin or increased liver enzymes
  • Intense abdominal pain that could signal pancreatitis.

Long-Term Side Effects:

Extended usage of this medication could lead to lasting impacts like:

  • Disturbances in electrolyte levels
  • Decrease in kidney function
  • Potential elevation in blood glucose levels.

long-term side effects of benazepril

Please remember that this medication won't cure your blood pressure, but it can assist in managing it. It is essential to follow the regimen consistently to effectively reduce and maintain your blood pressure levels. There is a possibility that you may need to take blood pressure medication for the long term.

stopping amlodipine side effects

Suddenly stopping this medication could lead to a recurrence or exacerbation of chest pain or high blood pressure. It's advisable to consult your doctor on the effective method to gradually decrease the dosage before discontinuing it entirely. It's common to experience a headache after taking a dose of this medication.

side effects of missing a dose of amlodipine

If you forget to take your medication, your blood pressure or chest discomfort could worsen, potentially resulting in complications, like a stroke or heart attack.

Important Precautions

Interaction with Other Medications:

It's important to talk to your healthcare provider about the medications you're currently taking, especially because Amlodipine/Benazepril can have interactions, with:

  • NSAIDs, which might reduce the effectiveness of the antihypertensive effects
  • Lithium potentially worsens lithium toxicity
  • Some diuretics increasing the chances of renal impairment.

Contraindications: Conditions and Risks:

Patients should steer clear of this medication if they have;

  • Experienced angioedema in the past due to ACE inhibitor therapy
  • renal artery stenosis
  • Known sensitivity to any ingredient, in the medication

Warnings: Potential Health Risks:

Before starting Amlodipine/Benazepril patients need to know about the following risks; low blood pressure, especially right after the first dose and in individuals with low salt/fluid levels Harmful effects on the fetus so its best avoided during pregnancy Potential reduction in white blood cells or a condition called agranulocytosis in patients, with kidney issues or certain autoimmune diseases

bananas and amlodipine

There are no documented interactions between amlodipine and bananas.. It's worth noting that bananas might interact with other blood pressure medications known as angiotensin converting enzyme (ACE) inhibitors. Combining an ACE inhibitor, with banana consumption could potentially raise your potassium levels to an extent.

amlodipine and alcohol

Sure you're allowed to have alcohol along, with amlodipine. However consuming alcohol can potentially amplify the blood pressure lowering effects of amlodipine beyond what's necessary. This might result in feelings of drowsiness, dizziness or even trigger a headache. In case you experience any of these symptoms it would be advisable to refrain from drinking alcohol while undergoing amlodipine treatment.

amlodipine and grapefruit

Avoid consuming grapefruit juice when taking amlodipine as it can enhance the drugs effects and potentially worsen side effects. To minimize risks it may be necessary to refrain from consuming grapefruit or its juice while using amlodipine.

Handling and Storage

Proper Storage Conditions:

For Amlodipine/Benazepril to work effectively it's best to keep it in a dry place at room temperature and away, from direct sunlight.

Handling Precautions to Ensure Safety:

Remember to touch the medication with dry hands and make sure to tightly close the cap after using it to prevent any contamination or deterioration of the drug.

Interactions with Other Drugs

Known Drug Interactions and Consequences:

The active ingredients in Amlodipine/Benazepril may interact with medications potentially reducing the effectiveness of treatment or worsening side effects. It's crucial to seek advice from a healthcare, about all the medications you are currently taking.

Food and Lifestyle Interactions:

When taking this medication patients should steer clear of the following; Consuming foods, in potassium or using supplements as they may cause hyperkalemia Drinking alcohol as it can worsen dizziness and raise the chances of low blood pressure

Overdosage

Symptoms of Overdose:

Taking too much Amlodipine/Benazepril can lead to serious issues like:

  • Extreme low blood pressure
  • Shock Imbalance, in electrolytes

Immediate Actions and Antidote Information:

If someone overdoses it's important to get help right away. Providing care and keeping an eye on signs and fluids are crucial.

Careful Administration

Monitoring Requirements:

To ensure the utilization of the medication, it is essential to regularly monitor blood pressure, kidney function, and electrolyte levels for dosage adjustments.

Adjustments During Therapy:

Based on how the patient reacts and the test results adjustments, to the dosage may be necessary to improve treatment effectiveness and reduce risks.

Amlodipine / Benazepril FAQ

How long does it take for amlodipine to work?

When you begin taking amlodipine, it begins to take action away, but it might take a few weeks to see its full impact. If you're using amlodipine to manage blood pressure you might not experience any noticeable symptoms.

Foods to avoid when taking amlodipine

Consuming quantities of grapefruit or grapefruit juice can elevate the levels of amlodipine in your system and potentially exacerbate its side effects. If you experience this, it might be necessary to refrain from consuming grapefruit or grapefruit juice while on amlodipine medication.

How long does it take for amlodipine to lower blood pressure?

When you begin taking amlodipine, it begins to have an effect, but it might take a few weeks to reach its full potential. If you're using amlodipine to manage blood pressure, you might not experience any noticeable symptoms. As a result, you may not perceive any changes when you start taking amlodipine.

What vitamins should not be taken with amlodipine?

If you're considering using St. John wort, a treatment for depression, it may impact the effectiveness of amlodipine. It's advisable to consult your doctor before starting St. Johns wort. The safety of combining herbal remedies or supplements with amlodipine has not yet been conclusively established.

What should you avoid when taking amlodipine?

antibiotics such as clarithromycin, erythromycin,  or rifampicin.

When to take amlodipine?

You can choose to take it at any time during the day, but aim to take it at a consistent time daily. Amlodipine tablets and liquid can be taken with or without food. Swallow the amlodipine tablets whole. Remember to drink water when taking both the tablets and liquid form.

Why take amlodipine at bedtime?

Some research has indicated that consuming medications such as amlodipine at night can be more effective in reducing blood pressure compared to taking them in the morning. Conversely there are also findings suggesting that taking these medications at night may lead to a drop, in blood pressure during sleep hours.

Why do i take amlodipine and metoprolol together?

Amlodipine and Metoprolol are effective in lowering blood pressure. Amlodipine functions as a calcium channel blocker, aiding in the relaxation of blood vessels, while Metoprolol acts as a beta blocker that specifically targets the heart to decrease its pace. When used in combination, they collaborate to enhance the heart's effectiveness in circulating blood throughout the body.

What painkillers can I take with amlodipine?

Paracetamol alongside amlodipine is safe to use.

How quickly does amlodipine work?

When you begin taking amlodipine, it begins to take effect away. However, it may take a week to experience its full benefits. If you suffer from angina, you may still have episodes of chest pain. In some cases you might notice that the pain worsens when you first start using amlodipine.

What should be avoided when taking amlodipine?

Consuming quantities of grapefruit or grapefruit juice can elevate the levels of amlodipine in your system, potentially exacerbating its side effects. If you experience this issue, it may be necessary to refrain from consuming grapefruit or grapefruit juice while using amlodipine.

How much amlodipine can you take?

Some individuals might begin with a 2.5 mg dosage daily. Your physician can modify your dosage as required. Typically it does not exceed 10 mg, per day.

How much amlodipine lowers BP?

Amlodipine treatment resulted in a decrease in systolic blood pressure of 12.2 mmHg (as shown in the graph with a 95% confidence interval of 10.3 to 14.0) compared to placebo (P<0.001). When examining all study groups where participants were treated with amlodipine, the office-measured systolic blood pressure showed a reduction of 17.5 mmHg (range 5.3 to 35).

How long does benazepril stay in your system?

The decrease in blood pressure can last for a minimum of 24 hours, though it might weaken in some individuals towards the end.

What is benazepril used for in dogs?

Benazepril is commonly recommended for dogs and cats to manage heart conditions, hypertension and kidney issues. These medications aid in improving blood circulation. Are frequently paired with other treatments to enhance the well being of your furry companion.

What is the difference between benazepril and benazepril hcl?

Benazepril Hydrochloride is the salt form of benazepril which's an angiotensin converting enzyme (ACE) inhibitor that contains carboxyl and has antihypertensive properties. Benazepril is converted into its form, benazeprilat as it functions as a prodrug.

What is amlodipine benazepril used for?

Amlodipine and benazepril are medications that work together to manage blood pressure, also known as hypertension.

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