Chlorthalidone
Introduction
Composition and Properties
How it Works
Uses of Chlorthalidone
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Chlorthalidone is a diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions. It improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule cells in the kidney. The exact mechanism of its anti-hypertensive effect is under debate, but there is strong evidence that thiazide diuretics like chlorthalidone reduce the risk of stroke, myocardial infarction, heart failure, and cardiovascular all-cause mortality in patients with hypertension. The ALLHAT trial confirmed the role of thiazide diuretics as first-line therapy and demonstrated that chlorthalidone had a statistically significant lower incidence of stroke and heart failure compared to other medications. Chlorthalidone also has pleiotropic effects that differentiate it from other diuretics1.
Off-Label Uses
Dosage and Administration
Side Effects
Warnings and Contraindications
Important Precautions
Interactions
Administration to Special Populations
Handling Precautions
Overdose Management
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