Labetalol

Name: Labetalol
Brand: Labetalol
SKU: 1448

Labetalol is an alpha and beta blocker that is prescribed to manage hypertension. It eases blood vessels and slows the heart rate thus helping to lower blood pressure.

US Brand Name

Normodyne

Generic Name

Labetalol

Other Brand Name

Lobet, Hybloc

Packing

Manufacturer

Samarth Pharma

Form

Tablet

Strength

100 mg

Country

India

100 mg 50 tablets USD $54.50

200 mg 50 tablets USD $89.50 out of stock

Labetalol

I. Introduction
II. Uses of Labetalol
III. How Labetalol Works
IV. Composition of Labetalol
V. Dosage and Administration
VI. Common Side Effects
VII. Less Common Side Effects and Complications
VIII. Warnings and Contraindications
- Contraindications with Other Medical Conditions
- Contraindications with Specific Populations
IX. Interaction with Other Drugs
X. Careful Administration and Important Precautions
XI. Special Populations
XII. Overdosage
XIII. Storage Guidelines
XIV. Handling Precautions
- Precautions During Handling and Dispensing
- Safety Measures for Healthcare Providers

I. Introduction

Brief Overview of Labetalol

Historical Background

Importance in Modern Medicine

II. Uses of Labetalol

Management of Hypertension

Labelatol First line treatment; Primarily used as a medication to lower blood pressure. Long term control; Effective, for managing hypertension.

References:

¹: Labetalol Uses, Side Effects & Warnings - Drugs.com ²: Labetalol: Side Effects, Dosage, Uses, and More - Healthline ³: Labetalol - National Center for Biotechnology Information ⁴: Labetalol: MedlinePlus Drug Information ⁵: Labetalol: a review of its pharmacology, pharmacokinetics … - PubMed ⁶

Use in Hypertensive Crises

Labetalol is a beta-blocker that is used to treat hypertension (high blood pressure) by causing the heart to beat more slowly and with less force ¹. It is a first-line treatment for hypertensive emergencies, severe hypertension with signs of damage to target organs such as the brain, heart, or kidneys ². Labetalol can rapidly lower blood pressure without causing reflex tachycardia or a significant reduction in heart rate ³. It can also be used for perioperative management of hypertension by anesthesia providers ³. Labetalol is useful for most hypertensive emergencies, except acute pulmonary edema or aortic dissection ⁴. It is also preferred for pregnancy-related hypertensive emergency or acute ischemic stroke ⁴. Labetalol can be given as an intravenous (IV) push or infusion, depending on the severity and urgency of the situation ¹ ².

References:

¹: Labetalol: Side Effects, Dosage, Uses, and More - Healthline ²: Hypertensive Emergencies - Cardiovascular Disorders - Merck Manuals … ³: Labetalol - National Center for Biotechnology Information ⁴: Hypertensive Emergency: Pearls and Pitfalls for the ED Physician

Treatment of Pheochromocytoma Preoperatively

Labetalol is a beta-blocker that can lower blood pressure and relieve symptoms of pheochromocytoma, a rare tumor that produces excess catecholamines (adrenaline and noradrenaline) ¹ ². Labetalol can block alpha and beta receptors, preventing the surge of catecholamines that occurs during surgery or stress ³ ⁴. Labetalol can be given before surgery to stabilize the blood pressure and reduce the risk of complications such as stroke, heart attack, or arrhythmia ⁵ ⁶. However, labetalol is not a first-line treatment for pheochromocytoma, and it should be used with caution in some patients, such as those with asthma, heart failure, or diabetes ¹ ⁷. Therefore, labetalol should only be used under the guidance of a doctor who can monitor its effects and adjust the dosage accordingly.

Learn more:

1. studybuff.com 2. bing.com 3. update.com 4. ncbi.nlm.nih.gov 5. medicine.com 6. academic.oup.com 7. mayoclinic.org

Off-Label Uses

Labetalol is a beta-blocker that is used to treat high blood pressure and heart conditions. It is not approved by the FDA for other purposes, but some doctors may prescribe it off-label for certain situations. Off-label use means that a drug is used for a different purpose than what it was approved for.

One of the off-label uses of labetalol is to prevent migraines. Migraines are severe headaches that can cause nausea, vomiting, sensitivity to light and sound, and other symptoms. Beta-blockers like labetalol can prevent migraines by reducing the effects of adrenaline on the blood vessels in the brain. Adrenaline can cause the blood vessels to constrict and dilate, which can trigger a migraine attack. By blocking adrenaline, labetalol can help prevent or reduce the frequency of migraines ¹ ².

Another off-label use of labetalol is to manage tachycardia caused by anxiety. Tachycardia is a condition where the heart beats faster than normal, which can cause chest pain, shortness of breath, dizziness, and palpitations. Anxiety can cause tachycardia by stimulating the release of adrenaline, which makes the heart beat faster and harder. Beta-blockers like labetalol can help reduce tachycardia by slowing down the heart rate and lowering the blood pressure ³ ⁴.

However, labetalol is not a cure for anxiety or migraines, and it may not work for everyone. It also has some side effects and contraindications that should be considered before using it. Therefore, labetalol should only be used under the guidance of a doctor who can monitor its effects and adjust the dosage accordingly.

References:

¹: Beta-Blockers for Migraine: Treatment, Side Effects, More - Healthline ²: Labetalol: 7 things you should know - Drugs.com ³: Beta-Blockers for Anxiety: Benefits, Side Effects, and Risks - Healthline ⁴: Labetalol: Side Effects, Dosage, Uses, and More - Healthline