Micardis Plus

Micardis Plus is a medication blend created to help control blood pressure by combining Telmisartan—an angiotensin II receptor blocker—and Hydrochlorothiazide—a thiazide diuretic, for a two-pronged approach to lowering blood pressure levels.

This medicine is mainly prescribed for individuals with blood pressure who need a mix of treatments to reach the best control of their blood pressure levels, particularly for those who have not seen enough improvement with just one type of treatment.

Micardis Plus has received FDA approval for its efficacy and safety in treating hypertension. It falls under the category of antihypertensive medications, classified specifically as a combination drug targeting multiple pathways.

Each tablet contains:

• Telmisartan: Blocks the angiotensin II receptor, reducing vasoconstriction and lowering blood pressure.
• Hydrochlorothiazide: Promotes the excretion of excess salt and water, reducing fluid buildup and aiding blood pressure management.

The nonactive components, like magnesium stearate and povidone, help uphold both the structure and absorption of tablets while not impacting their effectiveness in treating conditions.

Micardis Plus comes in strengths such as 40 mg / 12. 50. 80 Mg / 25 mg to address levels of severity in hypertension.

Telmisartan works as a blocker for the AT₁ receptor, showing an affinity than both losartan and its metabolite EXP3174 do in experiments conducted so far. The detachment of telmisartan from the AT₁ receptor happens at a greater rate compared to losartan and EXP3174 indicating a form of lasting antagonism, in practical terms.

Telmisartan and a combination of a medicine called amlodipine may be prescribed either by itself or in conjunction with medications to manage blood pressure (hypertension). Elevated blood pressure can impose strain on the heart and blood vessels over time; if unaddressed for a period of time can lead to compromised function of the heart and arteries.

Side effects from the treatment were less common in patients who took telmisartan (28%) compared to those who were on lisinopril.

Olmesartan effectively lowered blood pressure levels throughout the day and night when compared to telmisartan.

Telmisartan showed effectiveness in managing blood pressure compared to valsartan over the 24-hour dosing period and especially in the last 6 hours before dosaging time. Both medications were well received by patients with side effects being mild to moderate in nature.

Both telmisartan and candesartan are recognized as ATl receptor blockers that provide cardiac protection benefits. Enough though telmisartan stands out for its ability to partially stimulate the peroxisome proliferator—activated receptor gamma (PPAR gamma).

Even though both treatments lowered blood pressure readings, on average (MAP), telmisartan showed an antihypertensive effect compared to irbesartan, which allows for once-a-day dosing to improve patient adherence to the medication regimen.

Micardis Plus is a cornerstone therapy for managing high blood pressure, ensuring consistent control to reduce long-term risks.

Improving blood pressure profiles greatly reduces the chances of experiencing heart attacks, strokes, and other cardiovascular incidents.

Regular use of this medicine not helps manage blood pressure but also offers protection, against potential issues related to the brain and heart.

Patients with comorbid conditions, such as diabetes or chronic kidney disease, find particular advantage in this comprehensive therapy.

Recent findings indicate that it may be helpful in slowing down the advancement of kidney disease by decreasing protein in urine and maintaining kidney function.

Patients with kidney problems have seen improvements in their albuminuria levels with this treatment option, which also helps protect the kidneys.

Telmisartan is considered advantageous for bodybuilding as an angiotensin II receptor blocker since its use can enhance the function of muscles and boost energy expenditure while also positively impacting glucose and lipid metabolism.

Micardis Plus is currently under investigation as a remedy for people with high blood pressure issues, which brings optimism to those who do not respond well to traditional treatments.

Telmisartan has been linked to heart-related issues in individuals with dysfunction (ED). It is known to enhance function and improve the quality of one's sex life due to its proven properties.

It is commonly utilized to manage hypertension in felines and kidney ailments in both felines and canines, albeit its application for treating kidney diseases in these animals is considered 'off-label.'

Ongoing studies are looking into how it can help with heart conditions, like heart failure, with preserved ejection fraction (HFPEF).

The combination works synergistically:

• Telmisartan blocks vasoconstriction, improving arterial dilation.
• Hydrochlorothiazide reduces circulating fluid volume, enhancing blood pressure reduction.

Micardis effectively maintains consistent blood pressure regulation by addressing various mechanisms.

This combination treatment helps reduce the workload on the heart and enhances function for overall heart health.

Typically, you would begin with a dose of 40 mg of one component and 12 mg of another component, which may be adjusted according to how your body responds to it.

The typical daily dosage generally does not exceed 80 mg. For children, the appropriate dosage should be prescribed by a healthcare professional.

Patients who have issues with their kidneys or liver may need to consider using dosages or different treatment options to prevent any side effects.

It's important to take Micardis Plus at the time every day. Whether with or without food. In order to keep your blood pressure steady.

Elderly patients often require cautious titration and monitoring for hypotension and electrolyte imbalances.

These may include:

• Dizziness
• Fatigue
• Dry mouth

These include electrolyte disturbances, hyperuricemia, and mild skin rashes.

Rarely, patients may experience angioedema, severe hypotension, or acute kidney injury.

Experiencing kidney issues may manifest as reduced frequency of urination and swelling in the feet or hands along with weight gain.

Telmisartan has the potential to lower your blood pressure to a point where you might experience dizziness, lightheadedness, or headaches.

If someone experiences reactions like rashes or swelling or struggles to breathe, they should seek urgent medical help right away.

Micardis Plus is strictly contraindicated in individuals with hypersensitivity to Telmisartan, Hydrochlorothiazide, or any of its excipients. Administering the medication under these conditions could precipitate severe allergic reactions, including anaphylaxis.

Patients with existing liver or kidney issues should be careful when it comes to their health management plan, especially if they have conditions, like narrowing of both arteries or low fluid levels, as close monitoring is necessary to avoid worsening symptoms.

Micardis Plus should not be used during pregnancy and breastfeeding due to the risk of harm to the fetus and the potential transfer of substances to the baby through breast milk.

Clinical information on utilizing Micardis Plus in children is scarce; therefore, it is advisable to exercise caution when considering off-label use. Instead, focus on treatments that have strong backing from pediatric research studies.

Combining Micardis Plus with other antihypertensive agents may potentiate hypotensive effects. While this can be beneficial, excessive blood pressure reduction must be avoided to prevent symptoms such as dizziness or fainting.

Concomitant use of diuretics can amplify diuretic-induced electrolyte imbalances. NSAIDs, including COX-2 inhibitors, may attenuate the antihypertensive effects of Micardis Plus, and lithium toxicity risk increases due to reduced renal clearance.

Simultaneous use of potassium supplements, potassium-sparing diuretics, or ACE inhibitors increases hyperkalemia risk. Monitoring serum potassium levels is essential in such cases.

Patients on multiple medications should undergo thorough drug interaction assessments. Polypharmacy increases the likelihood of adverse effects, necessitating vigilant oversight.

Telmisartan and alcohol may work together in reducing your blood pressure. This could lead to symptoms like headaches, dizziness, and lightheadedness.

Regular monitoring of serum electrolytes, including potassium and sodium, is crucial to prevent complications such as hypokalemia or hyperkalemia, particularly in high-risk patients.

Patients with compromised kidney or liver function require dosage adjustments and frequent renal and hepatic function assessments to mitigate potential toxicity.

Potassium supplements, potassium-containing salt substitutes (No Salt, Morton Salt Substitute, and others), and even high-potassium foods (including Noni juice) should be avoided by those taking telmisartan.

Induced hyperuricemia could lead to gout flare-ups, and diabetic individuals might notice changes in their glucose tolerance levels. It's advised to keep an eye on both acid and blood sugar levels for proper monitoring.

Implement supportive care for common side effects, such as dizziness or fatigue. For severe adverse events, immediate discontinuation and medical intervention are imperative.

Suddenly stopping telmisartan can lead to an increase in blood pressure and unpleasant side effects like headaches and nausea along with heightened anxiety levels while also raising the likelihood of experiencing a stroke or heart attack.

In elderly individuals, adjustments may be necessary due to altered pharmacokinetics and comorbidities. Close monitoring for signs of orthostatic hypotension and electrolyte disturbances is critical.

Micardis Plus should be avoided during pregnancy due, to its effects on the fetus so healthcare providers need to consider safer treatment options, for pregnant women.

As the safety profile for lactating women is not well-established, discontinuation of breastfeeding or alternative therapies should be considered.

Pediatric use is generally not recommended due to insufficient safety and efficacy data. Off-label use should only be pursued under stringent medical supervision.

Overdose may manifest as pronounced hypotension, dizziness, electrolyte imbalances, or acute renal failure. Immediate recognition of these symptoms is vital.

In cases of overdose, initiate supportive care, including volume repletion and correction of electrolyte abnormalities. Dialysis is ineffective for Telmisartan but may aid in removing Hydrochlorothiazide.

Monitor patients for persistent renal or cardiovascular complications post-overdose. Comprehensive follow-up care ensures full recovery and prevents recurrence.

Please keep Micardis Plus in a dry place, at temperatures of 30°C, to maintain its effectiveness and shield it from light and moisture.

Dispose of unused or expired tablets through approved pharmaceutical take-back programs to prevent accidental ingestion or environmental contamination.

Keep Micardis Plus out of reach of children and pets. Use child-resistant packaging to minimize accidental exposure.

Micardis Plus is a medication for blood pressure that provides two advantages for controlling blood pressure effectively. It's important to stick to the recommended doses and keep track of your progress to get the most out of its healing properties.

Before initiating therapy, consult a healthcare provider to evaluate individual risks and benefits. Regular follow-ups ensure safe and effective treatment outcomes.

Consistent use of Micardis Plus, combined with lifestyle modifications, is key to achieving long-term cardiovascular health and mitigating hypertension-related complications.

What is Micardis Plus used for?

Micardis Plus is prescribed for the treatment of high blood pressure, also known as hypertension.

Which is better Micardis or losartan?

Micardis

Does Micardis plus affect kidneys?

In some instances, Micardis may trigger a situation where skeletal muscle tissue breaks down and could potentially lead to kidney failure.

Can you take Micardis and amlodipine together?

There were no interactions between amlodipine and Micardis.

What to avoid when taking Micardis?

A mix of telmisartan and alcohol might work together to reduce your blood pressure further and lead to symptoms like headaches, dizziness, or lightheaded, fainting spells, and changes in your pulse rate or heart rate.

What is the most common side effect of telmisartan?

Dizziness, lightheadedness, or fainting

Is Micardis a good blood pressure medicine?

Micardis assists in managing blood pressure and may also help prevent the onset of complications; however, it does not provide a cure for the condition.

Is telmisartan safe for kidneys?

Telmisartan has been shown to be successful and safe in decreasing proteinuria in individuals with kidney disease.

What foods should you avoid while taking telmisartan?

It's important for individuals who are prescribed telmisartan to steer off potassium supplements like salt substitutes (such as No Salt or Morton Salt Substitute) as well as foods high in potassium, like Nonu juice, unless advised differently by their healthcare provider.

What is the generic name for Micardis?

Telmisartan

Can you take Micardis and metformin together?

Yes

How long should telmisartan be taken?

Your blood pressure might drop within 2 weeks of starting your treatment; however, it could take up to 4 weeks for you to feel the effects of telmisartan.

What are the positive effects of telmisartan?

Numerous clinical studies utilizing ABPM have showcased its ability to lower blood pressure during the early morning period. It's noteworthy that telmisartan has proven effective in mitigating the surge in early morning blood pressure levels.

How much BP does telmisartan reduce?

Up to 15.5 and 10.5 mm Hg

Can you take vitamin C with telmisartan?

No evidence of any interactions was discovered between telmisartan and Vitamin C.

What should not be taken with telmisartan?

Medications, like aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen (sold as Motrin or Advil) and naproxen (known as Naprosyn or Aleve) along with COX 02 inhibitors such as celecoxib (marketed under the brand name Celebrez).